What compounds affect the Dual Incision in GG-NER pathway?

63 compounds in the BiohacksAI corpus have documented interactions with genes in the Dual Incision in GG-NER pathway (Reactome ID: R-HSA-5696400). These compounds target 5 genes within this pathway.

What genes are in the Dual Incision in GG-NER pathway?

The Dual Incision in GG-NER pathway involves 5 genes. Key genes include: ERCC3, PARP1, PCNA, POLK, RBX1.

Dual Incision in GG-NER

REACTOME PATHWAY

Reactome: R-HSA-56964005 genes63 compounds

The Dual Incision in GG-NER pathway (Reactome ID: R-HSA-5696400) involves 5 genes and is affected by 63 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ERCC3 PARP1 PCNA POLK RBX1

Compounds Affecting Dual Incision in GG-NER

#	Compound	Targets Hit	Studies
1	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
2	Daunorubicin	—	298
3	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
4	Quercetin	—	300
5	Ethidium	—	300
6	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
7	alpha-Linolenic Acid	—	300
8	Carmine Coloring matter from	—	300
9	Epinephrine	—	299
10	gamma-Linolenic Acid	—	300
11	Levodopa	—	297
12	Masoprocol	—	300
13	piceatannol	—	300
14	Arachidonic Acid	—	245
15	fisetin	—	78
16	candesartan cilexetil [Supplementary Concept]	—	300
17	Cefixime	—	300
18	Diiodotyrosine	—	300
19	Idarubicin	—	299
20	Methyldopa	—	297
21	Norepinephrine Precursor of epinephrine that is secreted by	—	298
22	DEAD-box RNA Helicases	—	169
23	Thioctic Acid	—	298
24	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
25	Catechin	—	51
26	plumbagin [Supplementary Concept]	—	300
27	Resveratrol	—	298
28	Rutin	—	300
29	Ampicillin Semi-synthetic derivative of penicillin that functions as	—	294
30	Anthralin	—	299
31	Aurintricarboxylic Acid	—	184
32	butein	—	158
33	Cefotetan	—	299
34	Cimetidine	—	299
35	Demeclocycline	—	5
36	Dihydroxyphenylalanine	—	300
37	Dithiazanine 3-Ethyl-2-(5-(3-ethyl-2-benzothiazolinylidene)-1,3- pentadienyl)benzothiazolium.	—	135
38	Catechin	—	300
39	Estramustine	—	300
40	o-Phthalaldehyde	—	300
41	Oxytetracycline	—	300
42	rafoxanide	—	172
43	streptonigrin	—	299
44	Suramin	—	300
45	Thioctic Acid	—	300
46	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	—	299
47	Bortezomib	—	300
48	Camptothecin	—	300
49	Clofarabine	—	298
50	Demecolcine	—	246

About the Dual Incision in GG-NER Pathway

The Dual Incision in GG-NER pathway is catalogued in Reactome (ID: R-HSA-5696400) and involves 5 genes. In the BiohacksAI corpus, 63 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ERCC3, PARP1, PCNA, POLK, RBX1.