Major pathway of rRNA processing in the nucleolus and cytosol
REACTOME PATHWAYThe Major pathway of rRNA processing in the nucleolus and cytosol pathway (Reactome ID: R-HSA-6791226) involves 6 genes and is affected by 9 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Major pathway of rRNA processing in the nucleolus and cytosol
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | pictilisib | — | 25 |
| 2 | egcg | — | 300 |
| 3 | Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is | — | 300 |
| 4 | sp600125 | — | 117 |
| 5 | Axitinib | — | 298 |
| 6 | Crizotinib | — | 298 |
| 7 | Afatinib | — | 297 |
| 8 | Dasatinib | — | 299 |
| 9 | alsterpaullone | — | 12 |
About the Major pathway of rRNA processing in the nucleolus and cytosol Pathway
The Major pathway of rRNA processing in the nucleolus and cytosol pathway is catalogued in Reactome (ID: R-HSA-6791226) and involves 6 genes. In the BiohacksAI corpus, 9 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CSNK1D, CSNK1E, RIOK1, RIOK2, RIOK3.