mRNA 3'-end processing
REACTOME PATHWAYThe mRNA 3'-end processing pathway (Reactome ID: R-HSA-72187) involves 4 genes and is affected by 27 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting mRNA 3'-end processing
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Anthralin | — | 299 |
| 2 | Hexachlorophene | — | 300 |
| 3 | Mometasone Furoate | — | 292 |
| 4 | Oxytetracycline | — | 300 |
| 5 | Thyroxine | — | 994 |
| 6 | Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS). | — | 300 |
| 7 | Aurintricarboxylic Acid | — | 184 |
| 8 | Calcimycin | — | 216 |
| 9 | Chlorhexidine | — | 299 |
| 10 | Clotrimazole | — | 296 |
| 11 | Fluspirilene | — | 74 |
| 12 | Tetracycline | — | 300 |
| 13 | Thyroxine | — | 300 |
| 14 | Azauridine | — | 300 |
| 15 | Carboxin | — | 174 |
| 16 | Digitoxin | — | 300 |
| 17 | Digoxin | — | 299 |
| 18 | Ethylenethiourea | — | 300 |
| 19 | Nadolol | — | 297 |
| 20 | Ouabain | — | 300 |
| 21 | streptonigrin | — | 299 |
| 22 | Sulfadiazine | — | 298 |
| 23 | Thioridazine | — | 35 |
| 24 | triflupromazine hydrochloride | — | 12 |
| 25 | Camptothecin | — | 300 |
| 26 | Quercetin | — | 300 |
| 27 | trichostatic acid [Supplementary Concept] related to trichostatin | — | 300 |
About the mRNA 3'-end processing Pathway
The mRNA 3'-end processing pathway is catalogued in Reactome (ID: R-HSA-72187) and involves 4 genes. In the BiohacksAI corpus, 27 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include HNRNPA1, PPP1CA, PTBP1, SF3B3.