Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane
REACTOME PATHWAYThe Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane pathway (Reactome ID: R-HSA-83936) involves 5 genes and is affected by 14 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Adenosine | — | 298 |
| 2 | Uridine | — | 300 |
| 3 | dilazep | — | 300 |
| 4 | lidoflazine | — | 278 |
| 5 | Ticagrelor | — | 299 |
| 6 | Sirolimus | — | 300 |
| 7 | Fidaxomicin | — | 295 |
| 8 | Gemcitabine | — | 300 |
| 9 | Papaverine | — | 299 |
| 10 | Rifaximin | — | 298 |
| 11 | Histamine | — | 300 |
| 12 | Fluoxetine | — | 1,000 |
| 13 | Cimetidine | — | 299 |
| 14 | Quinidine | — | 298 |
About the Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane Pathway
The Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane pathway is catalogued in Reactome (ID: R-HSA-83936) and involves 5 genes. In the BiohacksAI corpus, 14 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include SLC28A1, SLC28A2, SLC28A3, SLC29A1, SLC29A4.