RAB GEFs exchange GTP for GDP on RABs
REACTOME PATHWAYThe RAB GEFs exchange GTP for GDP on RABs pathway (Reactome ID: R-HSA-8876198) involves 5 genes and is affected by 18 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting RAB GEFs exchange GTP for GDP on RABs
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Pueraria | — | 300 |
| 2 | Genistein | — | 300 |
| 3 | pterostilbene | — | 299 |
| 4 | amlexanox | — | 96 |
| 5 | kenpaullone | — | 8 |
| 6 | Leflunomide | — | 297 |
| 7 | Niclosamide | — | 299 |
| 8 | pd98059 | — | 7 |
| 9 | Phenelzine | — | 297 |
| 10 | Riluzole | — | 298 |
| 11 | tyrphostin ag 1295 | — | 1 |
| 12 | Biotin | — | 297 |
| 13 | myricetin-3-O-galactopyranoside [Supplementary Concept] | — | 300 |
| 14 | Oxytetracycline | — | 300 |
| 15 | Guanosine Diphosphate | — | 300 |
| 16 | Guanosine Triphosphate Guanosine 5'-(tetrahydrogen triphosphate). | — | 300 |
| 17 | Crizotinib | — | 298 |
| 18 | hydroxyfasudil [Supplementary Concept] | — | 11 |
About the RAB GEFs exchange GTP for GDP on RABs Pathway
The RAB GEFs exchange GTP for GDP on RABs pathway is catalogued in Reactome (ID: R-HSA-8876198) and involves 5 genes. In the BiohacksAI corpus, 18 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AKT3, RAB7A, RAB9A, RIN1, ULK1.