What compounds affect the Receptor Mediated Mitophagy pathway?

31 compounds in the BiohacksAI corpus have documented interactions with genes in the Receptor Mediated Mitophagy pathway (Reactome ID: R-HSA-8934903). These compounds target 7 genes within this pathway.

What genes are in the Receptor Mediated Mitophagy pathway?

The Receptor Mediated Mitophagy pathway involves 7 genes. Key genes include: CSNK2A1, CSNK2A2, CSNK2B, MAP1LC3A, MAP1LC3B, SRC, ULK1.

Receptor Mediated Mitophagy

REACTOME PATHWAY

Reactome: R-HSA-89349037 genes31 compounds

The Receptor Mediated Mitophagy pathway (Reactome ID: R-HSA-8934903) involves 7 genes and is affected by 31 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CSNK2A1 CSNK2A2 CSNK2B MAP1LC3A MAP1LC3B SRC ULK1

Compounds Affecting Receptor Mediated Mitophagy

#	Compound	Targets Hit	Studies
1	Quercetin	—	300
2	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
3	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
4	fisetin	—	78
5	Kaempferols	—	300
6	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
7	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
8	chrysin	—	300
9	Vanillic Acid	—	300
10	ly294002	—	11
11	alsterpaullone	—	12
12	kenpaullone	—	8
13	Crizotinib	—	298
14	Novobiocin	—	300
15	Dichlororibofuranosylbenzimidazole	—	26
16	Adenylyl Imidodiphosphate 5'-Adenylic acid, monoanhydride with imidodiphosphoric acid.	—	300
17	sp600125	—	117
18	pictilisib	—	25
19	Axitinib	—	298
20	Dasatinib	—	299
21	Resveratrol	—	298
22	tyrphostin ag 1478	—	4
23	Sorafenib	—	300
24	Adenosine Monophosphate Adenine nucleotide containing	—	300
25	Afatinib	—	297
26	monorden	—	8
27	Niclosamide	—	299
28	Fluspirilene	—	74
29	Mestranol	—	300
30	Tolazamide	—	169
31	Trifluridine	—	295

About the Receptor Mediated Mitophagy Pathway

The Receptor Mediated Mitophagy pathway is catalogued in Reactome (ID: R-HSA-8934903) and involves 7 genes. In the BiohacksAI corpus, 31 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CSNK2A1, CSNK2A2, CSNK2B, MAP1LC3A, MAP1LC3B.