What compounds affect the RUNX3 regulates NOTCH signaling pathway?

28 compounds in the BiohacksAI corpus have documented interactions with genes in the RUNX3 regulates NOTCH signaling pathway (Reactome ID: R-HSA-8941856). These compounds target 4 genes within this pathway.

What genes are in the RUNX3 regulates NOTCH signaling pathway?

The RUNX3 regulates NOTCH signaling pathway involves 4 genes. Key genes include: CREBBP, EP300, KAT2A, KAT2B.

RUNX3 regulates NOTCH signaling

REACTOME PATHWAY

Reactome: R-HSA-89418564 genes28 compounds

The RUNX3 regulates NOTCH signaling pathway (Reactome ID: R-HSA-8941856) involves 4 genes and is affected by 28 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CREBBP EP300 KAT2A KAT2B

Compounds Affecting RUNX3 regulates NOTCH signaling

#	Compound	Targets Hit	Studies
1	plumbagin [Supplementary Concept]	—	300
2	egcg	—	300
3	Aurintricarboxylic Acid	—	184
4	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
5	DEAD-box RNA Helicases	—	169
6	Thioctic Acid	—	298
7	Arachidonic Acid	—	245
8	Oleic Acid	—	112
9	alpha-Linolenic Acid	—	300
10	candesartan cilexetil [Supplementary Concept]	—	300
11	Cisplatin	—	300
12	diallyl trisulfide	—	246
13	Estramustine	—	300
14	gamma-Linolenic Acid	—	300
15	Hexachlorophene	—	300
16	Iodoacetamide	—	300
17	Lithocholic Acid	—	300
18	Oxytetracycline	—	300
19	rafoxanide	—	172
20	Ritonavir	—	298
21	Thioctic Acid	—	300
22	Trazodone	—	297
23	Papaverine	—	299
24	Colchicine	—	300
25	Etazolate	—	66
26	Nocodazole Nocodazole is	—	215
27	11-hydroxypalmatine [Supplementary Concept]	—	238
28	np1	—	81

About the RUNX3 regulates NOTCH signaling Pathway

The RUNX3 regulates NOTCH signaling pathway is catalogued in Reactome (ID: R-HSA-8941856) and involves 4 genes. In the BiohacksAI corpus, 28 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CREBBP, EP300, KAT2A, KAT2B.