What compounds affect the Glutamate and glutamine metabolism pathway?

32 compounds in the BiohacksAI corpus have documented interactions with genes in the Glutamate and glutamine metabolism pathway (Reactome ID: R-HSA-8964539). These compounds target 3 genes within this pathway.

What genes are in the Glutamate and glutamine metabolism pathway?

The Glutamate and glutamine metabolism pathway involves 3 genes. Key genes include: GLS, GLUL, KYAT1.

Glutamate and glutamine metabolism

REACTOME PATHWAY

Reactome: R-HSA-89645393 genes32 compounds

The Glutamate and glutamine metabolism pathway (Reactome ID: R-HSA-8964539) involves 3 genes and is affected by 32 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

GLS GLUL KYAT1

Compounds Affecting Glutamate and glutamine metabolism

#	Compound	Targets Hit	Studies
1	caffeic acid	—	300
2	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
3	Resveratrol	—	298
4	2-Methoxyestradiol	—	300
5	ag490	—	14
6	alpha-Linolenic Acid	—	300
7	Ampicillin Semi-synthetic derivative of penicillin that functions as	—	294
8	Calcimycin	—	216
9	cefaclor	—	299
10	cefatrizine	—	114
11	Cefixime	—	300
12	daph	—	2
13	Diazooxonorleucine	—	32
14	Disulfiram	—	297
15	Physostigmine	—	300
16	ethopropazine	—	17
17	Fenoterol	—	300
18	hydroxyindoleacetic acid	—	300
19	Hydroxyurea	—	300
20	Metaproterenol	—	298
21	methoxyhydroxyphenylglycol	—	64
22	Normetanephrine	—	300
23	Oxytetracycline	—	300
24	Physostigmine	—	299
25	piceatannol	—	300
26	Reserpine	—	297
27	Rotenone	—	300
28	Suramin	—	300
29	Tolazamide	—	169
30	tyrphostin 9	—	2
31	Prednisolone	—	1,000
32	Tryptophan	—	300

About the Glutamate and glutamine metabolism Pathway

The Glutamate and glutamine metabolism pathway is catalogued in Reactome (ID: R-HSA-8964539) and involves 3 genes. In the BiohacksAI corpus, 32 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include GLS, GLUL, KYAT1.