Loss of function of MECP2 in Rett syndrome
REACTOME PATHWAYThe Loss of function of MECP2 in Rett syndrome pathway (Reactome ID: R-HSA-9005891) involves 5 genes and is affected by 14 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Loss of function of MECP2 in Rett syndrome
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Vorinostat | — | 299 |
| 2 | trichostatic acid [Supplementary Concept] related to trichostatin | — | 300 |
| 3 | scriptaid | — | 53 |
| 4 | Valproic Acid | — | 296 |
| 5 | pictilisib | — | 25 |
| 6 | Butyric Acid | — | 300 |
| 7 | Ursolic Acid | — | 300 |
| 8 | Celecoxib | — | 295 |
| 9 | Daunorubicin | — | 298 |
| 10 | Bortezomib | — | 300 |
| 11 | Camptothecin | — | 300 |
| 12 | Biotin | — | 297 |
| 13 | hydroxyfasudil [Supplementary Concept] | — | 11 |
| 14 | Sphingosine | — | 300 |
About the Loss of function of MECP2 in Rett syndrome Pathway
The Loss of function of MECP2 in Rett syndrome pathway is catalogued in Reactome (ID: R-HSA-9005891) and involves 5 genes. In the BiohacksAI corpus, 14 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include HDAC1, HDAC3, NCOR1, NCOR2, PRKACA.