What compounds affect the RHOU GTPase cycle pathway?

24 compounds in the BiohacksAI corpus have documented interactions with genes in the RHOU GTPase cycle pathway (Reactome ID: R-HSA-9013420). These compounds target 8 genes within this pathway.

What genes are in the RHOU GTPase cycle pathway?

The RHOU GTPase cycle pathway involves 8 genes. Key genes include: CDC42, EPHA2, GRB2, PAK4, PIK3R1, PIK3R2, PTK2B, SRC.

RHOU GTPase cycle

REACTOME PATHWAY

Reactome: R-HSA-90134208 genes24 compounds

The RHOU GTPase cycle pathway (Reactome ID: R-HSA-9013420) involves 8 genes and is affected by 24 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CDC42 EPHA2 GRB2 PAK4 PIK3R1 PIK3R2 PTK2B SRC

Compounds Affecting RHOU GTPase cycle

#	Compound	Targets Hit	Studies
1	Crizotinib	—	298
2	Dasatinib	—	299
3	Sorafenib	—	300
4	Quercetin	—	300
5	alsterpaullone	—	12
6	kenpaullone	—	8
7	pictilisib	—	25
8	ly294002	—	11
9	Sirolimus	—	300
10	Resveratrol	—	298
11	tyrphostin ag 1478	—	4
12	Adenosine Monophosphate Adenine nucleotide containing	—	300
13	Afatinib	—	297
14	monorden	—	8
15	Niclosamide	—	299
16	Wortmannin	—	300
17	alpelisib	—	227
18	torin 1	—	10
19	cycloheximide	—	300
20	Pioglitazone	—	297
21	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
22	Axitinib	—	298
23	casin	—	10
24	Dactinomycin	—	297

About the RHOU GTPase cycle Pathway

The RHOU GTPase cycle pathway is catalogued in Reactome (ID: R-HSA-9013420) and involves 8 genes. In the BiohacksAI corpus, 24 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CDC42, EPHA2, GRB2, PAK4, PIK3R1.