NOTCH3 Activation and Transmission of Signal to the Nucleus
REACTOME PATHWAYThe NOTCH3 Activation and Transmission of Signal to the Nucleus pathway (Reactome ID: R-HSA-9013507) involves 9 genes and is affected by 17 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting NOTCH3 Activation and Transmission of Signal to the Nucleus
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Dihydroergocristine | — | 187 |
| 2 | Aminoimidazole Carboxamide | — | 121 |
| 3 | Histamine | — | 300 |
| 4 | cefaclor | — | 299 |
| 5 | Cefdinir | — | 298 |
| 6 | Oxytetracycline | — | 300 |
| 7 | streptonigrin | — | 299 |
| 8 | Thioridazine | — | 35 |
| 9 | Dasatinib | — | 299 |
| 10 | Afatinib | — | 297 |
| 11 | tyrphostin ag 1478 | — | 4 |
| 12 | ag490 | — | 14 |
| 13 | tyrphostin 1 | — | 1 |
| 14 | Bisphenol A-Glycidyl Methacrylate | — | 197 |
| 15 | Kaempferols | — | 300 |
| 16 | Progesterone | — | 299 |
| 17 | Hexachlorophene | — | 300 |
About the NOTCH3 Activation and Transmission of Signal to the Nucleus Pathway
The NOTCH3 Activation and Transmission of Signal to the Nucleus pathway is catalogued in Reactome (ID: R-HSA-9013507) and involves 9 genes. In the BiohacksAI corpus, 17 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADAM10, APH1A, APH1B, EGFR, NCSTN.