Question 1

What compounds affect the NOTCH3 Intracellular Domain Regulates Transcription pathway?

Accepted Answer

32 compounds in the BiohacksAI corpus have documented interactions with genes in the NOTCH3 Intracellular Domain Regulates Transcription pathway (Reactome ID: R-HSA-9013508). These compounds target 5 genes within this pathway.

Question 2

What genes are in the NOTCH3 Intracellular Domain Regulates Transcription pathway?

Accepted Answer

The NOTCH3 Intracellular Domain Regulates Transcription pathway involves 5 genes. Key genes include: CREBBP, EP300, KAT2A, KAT2B, STAT1.

#	Compound	Targets Hit	Studies
1	egcg	—	300
2	Hexachlorophene	—	300
3	plumbagin [Supplementary Concept]	—	300
4	Aurintricarboxylic Acid	—	184
5	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
6	DEAD-box RNA Helicases	—	169
7	Thioctic Acid	—	298
8	Arachidonic Acid	—	245
9	Oleic Acid	—	112
10	alpha-Linolenic Acid	—	300
11	candesartan cilexetil [Supplementary Concept]	—	300
12	Cisplatin	—	300
13	diallyl trisulfide	—	246
14	Estramustine	—	300
15	gamma-Linolenic Acid	—	300
16	Iodoacetamide	—	300
17	Lithocholic Acid	—	300
18	Oxytetracycline	—	300
19	rafoxanide	—	172
20	Ritonavir	—	298
21	Thioctic Acid	—	300
22	Trazodone	—	297
23	Budesonide	—	1,000
24	Methylene Blue	—	200
25	Flurandrenolone	—	65
26	streptonigrin	—	299
27	Papaverine	—	299
28	Colchicine	—	300
29	Etazolate	—	66
30	Nocodazole Nocodazole is	—	215
31	11-hydroxypalmatine [Supplementary Concept]	—	238
32	np1	—	81

BiohacksAI

NOTCH3 Intracellular Domain Regulates Transcription

Genes in this Pathway

Compounds Affecting NOTCH3 Intracellular Domain Regulates Transcription

About the NOTCH3 Intracellular Domain Regulates Transcription Pathway