Biosynthesis of DPAn-3-derived protectins and resolvins

Q: What compounds affect the Biosynthesis of DPAn-3-derived protectins and resolvins pathway?

36 compounds in the BiohacksAI corpus have documented interactions with genes in the Biosynthesis of DPAn-3-derived protectins and resolvins pathway (Reactome ID: R-HSA-9026286). These compounds target 2 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-90262862 genes36 compounds

The Biosynthesis of DPAn-3-derived protectins and resolvins pathway (Reactome ID: R-HSA-9026286) involves 2 genes and is affected by 36 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ALOX15 ALOX5

Compounds Affecting Biosynthesis of DPAn-3-derived protectins and resolvins

#	Compound	Targets Hit	Studies
1	Masoprocol	—	300
2	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
3	Quercetin	—	300
4	Celecoxib	—	295
5	fisetin	—	78
6	Arachidonic Acid	—	245
7	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
8	Aurintricarboxylic Acid	—	184
9	Dipyrone	—	298
10	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
11	Catechin	—	51
12	alpha-Linolenic Acid	—	300
13	brl 50481	—	5
14	Cholecalciferol Derivative of 7-dehydroxycholesterol formed by ULTRAVIOLET RAYS breaking of	—	299
15	Dactinomycin	—	297
16	dihydroxyflavone	—	256
17	Dihydroxyphenylalanine	—	300
18	Ethidium	—	300
19	ethopropazine hydrochloride	—	2
20	Ethoxyquin Antioxidant; also	—	180
21	Hexachlorophene	—	300
22	Iodoacetamide	—	300
23	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
24	Linoleic Acid	—	300
25	Procarbazine	—	299
26	Pseudoephedrine	—	298
27	pterostilbene	—	299
28	piceatannol	—	300
29	butein	—	158
30	caffeic acid	—	300
31	Kaempferols	—	300
32	Resveratrol	—	298
33	Anthralin	—	299
34	Bufexamac	—	137
35	Indomethacin	—	297
36	Leukotriene A4 (2S-(2 alpha,3 beta(1E,3E,5Z,8Z)))-3-(1,3,5,8-Tetradecatetraenyl)oxiranebutanoic acid.	—	300

About the Biosynthesis of DPAn-3-derived protectins and resolvins Pathway

The Biosynthesis of DPAn-3-derived protectins and resolvins pathway is catalogued in Reactome (ID: R-HSA-9026286) and involves 2 genes. In the BiohacksAI corpus, 36 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ALOX15, ALOX5.