NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake

Q: What compounds affect the NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake pathway?

58 compounds in the BiohacksAI corpus have documented interactions with genes in the NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake pathway (Reactome ID: R-HSA-9031525). These compounds target 4 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-90315254 genes58 compounds

The NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake pathway (Reactome ID: R-HSA-9031525) involves 4 genes and is affected by 58 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

NR1H2 NR1H3 RXRA RXRB

Compounds Affecting NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake

#	Compound	Targets Hit	Studies
1	methyl 13-(alpha-naphthalene)aminodeisopropyldehydroabietate [Supplementary Concept]	—	161
2	Thyroxine	—	994
3	Progesterone	—	299
4	Calcitriol	—	300
5	Thyroxine	—	300
6	Gemfibrozil	—	297
7	Desmosterol	—	300
8	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
9	Dehydroepiandrosterone Sulfate	—	300
10	Sulindac	—	297
11	Vitamin	—	295
12	Aldosterone	—	300
13	Dactinomycin	—	297
14	Domperidone	—	299
15	Ethylene Chlorohydrin Used as	—	73
16	Phenol	—	297
17	Retinaldehyde	—	300
18	Ribitol	—	297
19	Sorbic Acid Mold and yeast inhibitor. Used as	—	300
20	Stavudine	—	298
21	Sulfanilamide	—	300
22	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	—	299
23	Xylitol	—	300
24	Arachidonic Acid	—	245
25	Genistein	—	300
26	Acetaminophen Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as	—	1,000
27	Quercetin	—	300
28	Testosterone	—	299
29	Acetaminophen Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as	—	293
30	Acetylcysteine	—	298
31	Adenosine	—	298
32	Anthraquinones Compounds based on ANTHRACENES which contain two KETONES in	—	300
33	Chloral Hydrate	—	298
34	Chloralose	—	300
35	Cilostazol	—	297
36	Diflubenzuron	—	300
37	Dihydrotestosterone	—	300
38	dimethyl formamide	—	260
39	Dimethylformamide	—	300
40	Diuron	—	300
41	Ethidium	—	300
42	Ezetimibe	—	296
43	Flutamide	—	298
44	Lutein	—	300
45	Niclosamide	—	299
46	Niflumic Acid	—	300
47	Nitrofurazone	—	300
48	Oxaprozin	—	181
49	Piperazine	—	299
50	Rosuvastatin Calcium	—	216

About the NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake Pathway

The NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake pathway is catalogued in Reactome (ID: R-HSA-9031525) and involves 4 genes. In the BiohacksAI corpus, 58 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include NR1H2, NR1H3, RXRA, RXRB.