What compounds affect the Activated NTRK2 signals through FYN pathway?

35 compounds in the BiohacksAI corpus have documented interactions with genes in the Activated NTRK2 signals through FYN pathway (Reactome ID: R-HSA-9032500). These compounds target 4 genes within this pathway.

What genes are in the Activated NTRK2 signals through FYN pathway?

The Activated NTRK2 signals through FYN pathway involves 4 genes. Key genes include: FYN, GRIN2B, NTRK2, SRC.

Activated NTRK2 signals through FYN

REACTOME PATHWAY

Reactome: R-HSA-90325004 genes35 compounds

The Activated NTRK2 signals through FYN pathway (Reactome ID: R-HSA-9032500) involves 4 genes and is affected by 35 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

FYN GRIN2B NTRK2 SRC

Compounds Affecting Activated NTRK2 signals through FYN

#	Compound	Targets Hit	Studies
1	Sorafenib	—	300
2	Crizotinib	—	298
3	Dasatinib	—	299
4	tyrphostin ag 1478	—	4
5	kenpaullone	—	8
6	Glutamic Acid	—	297
7	Glutamic Acid	—	300
8	Glycine	—	300
9	eliprodil	—	33
10	pentamidine	—	299
11	Dextromethorphan Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of	—	296
12	Levorphanol	—	297
13	Aspartic Acid	—	300
14	cycloserine	—	298
15	D-Aspartic Acid	—	29
16	Dextrorphan Dextro form of levorphanol. It acts as	—	300
17	Ethidium	—	300
18	Dextrothyroxine	—	134
19	Dizocilpine Maleate	—	300
20	Ibotenic Acid	—	300
21	Memantine AMANTADINE derivative that has some dopaminergic effects. It has been proposed as	—	34
22	Spermine	—	300
23	Resveratrol	—	298
24	Quercetin	—	300
25	Adenosine Monophosphate Adenine nucleotide containing	—	300
26	Afatinib	—	297
27	alsterpaullone	—	12
28	monorden	—	8
29	Niclosamide	—	299
30	Rosmarinic Acid	—	300
31	Genistein	—	300
32	egcg	—	300
33	Acetic Acid Product of	—	300
34	tyrosol	—	300
35	sp600125	—	117

About the Activated NTRK2 signals through FYN Pathway

The Activated NTRK2 signals through FYN pathway is catalogued in Reactome (ID: R-HSA-9032500) and involves 4 genes. In the BiohacksAI corpus, 35 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include FYN, GRIN2B, NTRK2, SRC.