Assembly and cell surface presentation of NMDA receptors

Q: What compounds affect the Assembly and cell surface presentation of NMDA receptors pathway?

36 compounds in the BiohacksAI corpus have documented interactions with genes in the Assembly and cell surface presentation of NMDA receptors pathway (Reactome ID: R-HSA-9609736). These compounds target 24 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-960973624 genes36 compounds

The Assembly and cell surface presentation of NMDA receptors pathway (Reactome ID: R-HSA-9609736) involves 24 genes and is affected by 36 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CAMK2B CAMK2D CASK GRIN1 GRIN2A GRIN2B GRIN2C TUBA1A TUBA1B TUBA1C TUBA3C TUBA3E TUBA4A TUBA8 TUBAL3 TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 TUBB8 TUBB8B

Compounds Affecting Assembly and cell surface presentation of NMDA receptors

#	Compound	Targets Hit	Studies
1	Colchicine	—	300
2	Nocodazole Nocodazole is	—	215
3	Vincristine	—	299
4	Noscapine	—	300
5	Podophyllotoxin	—	14
6	Demecolcine	—	246
7	Maytansine	—	300
8	vinblastine sulfate	—	81
9	Vorinostat	—	299
10	Glutamic Acid	—	297
11	Glutamic Acid	—	300
12	Glycine	—	300
13	pentamidine	—	299
14	Dextromethorphan Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of	—	296
15	Dextrorphan Dextro form of levorphanol. It acts as	—	300
16	Levorphanol	—	297
17	cycloserine	—	298
18	Aspartic Acid	—	300
19	D-Aspartic Acid	—	29
20	Ethidium	—	300
21	Dextrothyroxine	—	134
22	Dizocilpine Maleate	—	300
23	Ibotenic Acid	—	300
24	Spermine	—	300
25	eliprodil	—	33
26	Memantine AMANTADINE derivative that has some dopaminergic effects. It has been proposed as	—	34
27	KN 92 [Supplementary Concept] KN 93 isomer;	—	26
28	sp600125	—	117
29	Kynurenic Acid	—	300
30	Phenformin	—	300
31	Carvedilol	—	296
32	Ibogaine	—	300
33	Quercetin	—	300
34	Sorafenib	—	300
35	alsterpaullone	—	12
36	Crizotinib	—	298

About the Assembly and cell surface presentation of NMDA receptors Pathway

The Assembly and cell surface presentation of NMDA receptors pathway is catalogued in Reactome (ID: R-HSA-9609736) and involves 24 genes. In the BiohacksAI corpus, 36 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CAMK2B, CAMK2D, CASK, GRIN1, GRIN2A.