NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis

Q: What compounds affect the NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis pathway?

77 compounds in the BiohacksAI corpus have documented interactions with genes in the NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis pathway (Reactome ID: R-HSA-9623433). These compounds target 8 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-96234338 genes77 compounds

The NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis pathway (Reactome ID: R-HSA-9623433) involves 8 genes and is affected by 77 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

NCOA1 NCOR1 NCOR2 NR1H2 NR1H3 RXRA RXRB UGT1A3

Compounds Affecting NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis

#	Compound	Targets Hit	Studies
1	methyl 13-(alpha-naphthalene)aminodeisopropyldehydroabietate [Supplementary Concept]	—	161
2	Thyroxine	—	994
3	Progesterone	—	299
4	Calcitriol	—	300
5	Thyroxine	—	300
6	Gemfibrozil	—	297
7	Desmosterol	—	300
8	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
9	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
10	Vorinostat	—	299
11	Dehydroepiandrosterone Sulfate	—	300
12	Sulindac	—	297
13	Vitamin	—	295
14	Aldosterone	—	300
15	Dactinomycin	—	297
16	Domperidone	—	299
17	Ethylene Chlorohydrin Used as	—	73
18	Phenol	—	297
19	Retinaldehyde	—	300
20	Ribitol	—	297
21	Sorbic Acid Mold and yeast inhibitor. Used as	—	300
22	Stavudine	—	298
23	Sulfanilamide	—	300
24	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	—	299
25	Xylitol	—	300
26	Arachidonic Acid	—	245
27	Genistein	—	300
28	Acetaminophen Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as	—	1,000
29	Quercetin	—	300
30	Testosterone	—	299
31	Acetaminophen Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as	—	293
32	Acetylcysteine	—	298
33	Adenosine	—	298
34	Anthraquinones Compounds based on ANTHRACENES which contain two KETONES in	—	300
35	Chloral Hydrate	—	298
36	Chloralose	—	300
37	Cilostazol	—	297
38	Diflubenzuron	—	300
39	Dihydrotestosterone	—	300
40	dimethyl formamide	—	260
41	Dimethylformamide	—	300
42	Diuron	—	300
43	Ethidium	—	300
44	Ezetimibe	—	296
45	Flutamide	—	298
46	Lutein	—	300
47	Niclosamide	—	299
48	Niflumic Acid	—	300
49	Nitrofurazone	—	300
50	Oxaprozin	—	181

About the NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis Pathway

The NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis pathway is catalogued in Reactome (ID: R-HSA-9623433) and involves 8 genes. In the BiohacksAI corpus, 77 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include NCOA1, NCOR1, NCOR2, NR1H2, NR1H3.