NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis

Q: What compounds affect the NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis pathway?

58 compounds in the BiohacksAI corpus have documented interactions with genes in the NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis pathway (Reactome ID: R-HSA-9632974). These compounds target 3 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-96329743 genes58 compounds

The NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis pathway (Reactome ID: R-HSA-9632974) involves 3 genes and is affected by 58 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

NR1H3 RXRA RXRB

Compounds Affecting NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis

#	Compound	Targets Hit	Studies
1	methyl 13-(alpha-naphthalene)aminodeisopropyldehydroabietate [Supplementary Concept]	—	161
2	Thyroxine	—	994
3	Calcitriol	—	300
4	Thyroxine	—	300
5	Dehydroepiandrosterone Sulfate	—	300
6	Sulindac	—	297
7	Progesterone	—	299
8	Vitamin	—	295
9	Aldosterone	—	300
10	Dactinomycin	—	297
11	Domperidone	—	299
12	Ethylene Chlorohydrin Used as	—	73
13	Phenol	—	297
14	Retinaldehyde	—	300
15	Ribitol	—	297
16	Sorbic Acid Mold and yeast inhibitor. Used as	—	300
17	Stavudine	—	298
18	Sulfanilamide	—	300
19	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	—	299
20	Xylitol	—	300
21	Arachidonic Acid	—	245
22	Genistein	—	300
23	Acetaminophen Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as	—	1,000
24	Quercetin	—	300
25	Testosterone	—	299
26	Acetaminophen Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as	—	293
27	Acetylcysteine	—	298
28	Adenosine	—	298
29	Anthraquinones Compounds based on ANTHRACENES which contain two KETONES in	—	300
30	Chloral Hydrate	—	298
31	Chloralose	—	300
32	Cilostazol	—	297
33	Diflubenzuron	—	300
34	Dihydrotestosterone	—	300
35	dimethyl formamide	—	260
36	Dimethylformamide	—	300
37	Diuron	—	300
38	Ethidium	—	300
39	Ezetimibe	—	296
40	Flutamide	—	298
41	Gemfibrozil	—	297
42	Lutein	—	300
43	Niclosamide	—	299
44	Niflumic Acid	—	300
45	Nitrofurazone	—	300
46	Oxaprozin	—	181
47	Piperazine	—	299
48	Rosuvastatin Calcium	—	216
49	Rotenone	—	300
50	Sulfamethazine	—	300

About the NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis Pathway

The NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis pathway is catalogued in Reactome (ID: R-HSA-9632974) and involves 3 genes. In the BiohacksAI corpus, 58 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include NR1H3, RXRA, RXRB.