What compounds affect the Suppression of apoptosis pathway?

34 compounds in the BiohacksAI corpus have documented interactions with genes in the Suppression of apoptosis pathway (Reactome ID: R-HSA-9635465). These compounds target 4 genes within this pathway.

What genes are in the Suppression of apoptosis pathway?

The Suppression of apoptosis pathway involves 4 genes. Key genes include: CTSG, GSK3A, MAPK1, MAPK3.

Suppression of apoptosis

REACTOME PATHWAY

Reactome: R-HSA-96354654 genes34 compounds

The Suppression of apoptosis pathway (Reactome ID: R-HSA-9635465) involves 4 genes and is affected by 34 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CTSG GSK3A MAPK1 MAPK3

Compounds Affecting Suppression of apoptosis

#	Compound	Targets Hit	Studies
1	alsterpaullone	—	12
2	kenpaullone	—	8
3	plumbagin [Supplementary Concept]	—	300
4	pd98059	—	7
5	sp600125	—	117
6	fisetin	—	78
7	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
8	Sorafenib	—	300
9	trametinib	—	296
10	withaferin	—	300
11	tyrphostin ag 1478	—	4
12	Clotrimazole	—	296
13	Progesterone	—	299
14	2-Chloroadenosine 2-Chloroadenosine.	—	300
15	Benzalkonium Compounds	—	299
16	Calcimycin	—	216
17	daph	—	2
18	Diphenhydramine	—	14
19	ha1004	—	4
20	Lithocholic Acid	—	300
21	Loratadine	—	296
22	trequinsin hydrochloride	—	1
23	indirubin	—	300
24	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
25	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
26	chrysin	—	300
27	Kaempferols	—	300
28	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
29	Quercetin	—	300
30	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
31	Chlorhexidine	—	299
32	piceatannol	—	300
33	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
34	Bortezomib	—	300

About the Suppression of apoptosis Pathway

The Suppression of apoptosis pathway is catalogued in Reactome (ID: R-HSA-9635465) and involves 4 genes. In the BiohacksAI corpus, 34 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CTSG, GSK3A, MAPK1, MAPK3.