Defective DNA double strand break response due to BRCA1 loss of function

Q: What compounds affect the Defective DNA double strand break response due to BRCA1 loss of function pathway?

34 compounds in the BiohacksAI corpus have documented interactions with genes in the Defective DNA double strand break response due to BRCA1 loss of function pathway (Reactome ID: R-HSA-9663199). These compounds target 2 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-96631992 genes34 compounds

The Defective DNA double strand break response due to BRCA1 loss of function pathway (Reactome ID: R-HSA-9663199) involves 2 genes and is affected by 34 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

BARD1 BRCA1

Compounds Affecting Defective DNA double strand break response due to BRCA1 loss of function

#	Compound	Targets Hit	Studies
1	Methotrexate	—	289
2	Astemizole Antihistamine drug now withdrawn from	—	280
3	Azacitidine	—	298
4	Azacitidine	—	300
5	Calcimycin	—	216
6	Chlorhexidine	—	299
7	Ciclopirox	—	88
8	Colchicine	—	300
9	colchine	—	2
10	cycloheximide	—	300
11	Cytarabine	—	297
12	Demecolcine	—	246
13	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
14	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
15	dihydrorotenone	—	13
16	Fluspirilene	—	74
17	gedunin	—	54
18	Hexachlorophene	—	300
19	lidoflazine	—	278
20	Melphalan	—	300
21	Niclosamide	—	299
22	Nocodazole Nocodazole is	—	215
23	paxilline	—	42
24	Podophyllotoxin	—	14
25	rafoxanide	—	172
26	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
27	Trifluridine	—	295
28	Tubercidin	—	300
29	vinblastine sulfate	—	81
30	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
31	Resveratrol	—	298
32	calycosin	—	300
33	Semustine 4-Methyl derivative of LOMUSTINE; (CCNU).	—	97
34	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	—	299

About the Defective DNA double strand break response due to BRCA1 loss of function Pathway

The Defective DNA double strand break response due to BRCA1 loss of function pathway is catalogued in Reactome (ID: R-HSA-9663199) and involves 2 genes. In the BiohacksAI corpus, 34 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include BARD1, BRCA1.