Question 1

What compounds affect the Signaling by PDGFR in disease pathway?

Accepted Answer

27 compounds in the BiohacksAI corpus have documented interactions with genes in the Signaling by PDGFR in disease pathway (Reactome ID: R-HSA-9671555). These compounds target 8 genes within this pathway.

Question 2

What genes are in the Signaling by PDGFR in disease pathway?

Accepted Answer

The Signaling by PDGFR in disease pathway involves 8 genes. Key genes include: GRB2, KDR, PDGFRA, PIK3CB, PIK3R1, PIK3R2, STAT1, STAT3.

#	Compound	Targets Hit	Studies
1	pictilisib	—	25
2	ly294002	—	11
3	Sirolimus	—	300
4	Sorafenib	—	300
5	Quercetin	—	300
6	Dasatinib	—	299
7	tyrphostin ag 1295	—	1
8	Wortmannin	—	300
9	alpelisib	—	227
10	Axitinib	—	298
11	Avapritinib	—	246
12	Crizotinib	—	298
13	kenpaullone	—	8
14	sp600125	—	117
15	Vemurafenib	—	298
16	torin 1	—	10
17	Budesonide	—	1,000
18	Methylene Blue	—	200
19	egcg	—	300
20	Flurandrenolone	—	65
21	Hexachlorophene	—	300
22	streptonigrin	—	299
23	Resveratrol	—	298
24	Niclosamide	—	299
25	Fingolimod Hydrochloride	—	56
26	Celecoxib	—	295
27	Dactinomycin	—	297

BiohacksAI

Signaling by PDGFR in disease

Genes in this Pathway

Compounds Affecting Signaling by PDGFR in disease

About the Signaling by PDGFR in disease Pathway