Signaling by PDGFRA extracellular domain mutants
REACTOME PATHWAYThe Signaling by PDGFRA extracellular domain mutants pathway (Reactome ID: R-HSA-9673770) involves 7 genes and is affected by 21 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Signaling by PDGFRA extracellular domain mutants
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | pictilisib | — | 25 |
| 2 | ly294002 | — | 11 |
| 3 | Sirolimus | — | 300 |
| 4 | Wortmannin | — | 300 |
| 5 | alpelisib | — | 227 |
| 6 | torin 1 | — | 10 |
| 7 | Quercetin | — | 300 |
| 8 | Budesonide | — | 1,000 |
| 9 | Methylene Blue | — | 200 |
| 10 | egcg | — | 300 |
| 11 | Flurandrenolone | — | 65 |
| 12 | Hexachlorophene | — | 300 |
| 13 | streptonigrin | — | 299 |
| 14 | Resveratrol | — | 298 |
| 15 | Niclosamide | — | 299 |
| 16 | Fingolimod Hydrochloride | — | 56 |
| 17 | Celecoxib | — | 295 |
| 18 | tyrphostin ag 1295 | — | 1 |
| 19 | Dasatinib | — | 299 |
| 20 | Sorafenib | — | 300 |
| 21 | Dactinomycin | — | 297 |
About the Signaling by PDGFRA extracellular domain mutants Pathway
The Signaling by PDGFRA extracellular domain mutants pathway is catalogued in Reactome (ID: R-HSA-9673770) and involves 7 genes. In the BiohacksAI corpus, 21 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include GRB2, PDGFRA, PIK3CB, PIK3R1, PIK3R2.