What genes are in the Diseases of DNA Double-Strand Break Repair pathway?

The Diseases of DNA Double-Strand Break Repair pathway involves 9 genes. Key genes include: ATM, BARD1, BLM, BRCA1, DNA2, RAD51, RBBP8, SEM1, WRN.

Diseases of DNA Double-Strand Break Repair

Q: What compounds affect the Diseases of DNA Double-Strand Break Repair pathway?

63 compounds in the BiohacksAI corpus have documented interactions with genes in the Diseases of DNA Double-Strand Break Repair pathway (Reactome ID: R-HSA-9675136). These compounds target 9 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-96751369 genes63 compounds

The Diseases of DNA Double-Strand Break Repair pathway (Reactome ID: R-HSA-9675136) involves 9 genes and is affected by 63 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ATM BARD1 BLM BRCA1 DNA2 RAD51 RBBP8 SEM1 WRN

Compounds Affecting Diseases of DNA Double-Strand Break Repair

#	Compound	Targets Hit	Studies
1	Methotrexate	—	289
2	Astemizole Antihistamine drug now withdrawn from	—	280
3	Azacitidine	—	298
4	Azacitidine	—	300
5	Calcimycin	—	216
6	Chlorhexidine	—	299
7	Ciclopirox	—	88
8	Colchicine	—	300
9	colchine	—	2
10	cycloheximide	—	300
11	Cytarabine	—	297
12	Demecolcine	—	246
13	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
14	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
15	dihydrorotenone	—	13
16	Fluspirilene	—	74
17	gedunin	—	54
18	Hexachlorophene	—	300
19	lidoflazine	—	278
20	Melphalan	—	300
21	Niclosamide	—	299
22	Nocodazole Nocodazole is	—	215
23	paxilline	—	42
24	Podophyllotoxin	—	14
25	rafoxanide	—	172
26	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
27	Trifluridine	—	295
28	Tubercidin	—	300
29	vinblastine sulfate	—	81
30	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
31	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
32	Methylene Blue	—	200
33	Levodopa	—	297
34	streptonigrin	—	299
35	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
36	Resveratrol	—	298
37	calycosin	—	300
38	Semustine 4-Methyl derivative of LOMUSTINE; (CCNU).	—	97
39	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	—	299
40	Aurintricarboxylic Acid	—	184
41	Daunorubicin	—	298
42	Quercetin	—	300
43	Estramustine	—	300
44	Idarubicin	—	299
45	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
46	DEAD-box RNA Helicases	—	169
47	Thioctic Acid	—	298
48	Rosmarinic Acid	—	300
49	Dihydroxyphenylalanine	—	300
50	Vitamin K 3	—	300

About the Diseases of DNA Double-Strand Break Repair Pathway

The Diseases of DNA Double-Strand Break Repair pathway is catalogued in Reactome (ID: R-HSA-9675136) and involves 9 genes. In the BiohacksAI corpus, 63 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ATM, BARD1, BLM, BRCA1, DNA2.