Disorders of Developmental Biology
REACTOME PATHWAYThe Disorders of Developmental Biology pathway (Reactome ID: R-HSA-9675151) involves 9 genes and is affected by 15 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Disorders of Developmental Biology
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Vorinostat | — | 299 |
| 2 | trichostatic acid [Supplementary Concept] related to trichostatin | — | 300 |
| 3 | s adenosylhomocysteine | — | 300 |
| 4 | scriptaid | — | 53 |
| 5 | Valproic Acid | — | 296 |
| 6 | pictilisib | — | 25 |
| 7 | Butyric Acid | — | 300 |
| 8 | Ursolic Acid | — | 300 |
| 9 | Celecoxib | — | 295 |
| 10 | Daunorubicin | — | 298 |
| 11 | Bortezomib | — | 300 |
| 12 | Camptothecin | — | 300 |
| 13 | Biotin | — | 297 |
| 14 | hydroxyfasudil [Supplementary Concept] | — | 11 |
| 15 | Sphingosine | — | 300 |
About the Disorders of Developmental Biology Pathway
The Disorders of Developmental Biology pathway is catalogued in Reactome (ID: R-HSA-9675151) and involves 9 genes. In the BiohacksAI corpus, 15 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ASH2L, DPY30, HDAC1, HDAC3, NCOR1.