What compounds affect the Non-canonical inflammasome activation pathway?

52 compounds in the BiohacksAI corpus have documented interactions with genes in the Non-canonical inflammasome activation pathway (Reactome ID: R-HSA-9686114). These compounds target 4 genes within this pathway.

What genes are in the Non-canonical inflammasome activation pathway?

The Non-canonical inflammasome activation pathway involves 4 genes. Key genes include: CASP4, CASP5, GSDMD, IL1B.

Non-canonical inflammasome activation

REACTOME PATHWAY

Reactome: R-HSA-96861144 genes52 compounds

The Non-canonical inflammasome activation pathway (Reactome ID: R-HSA-9686114) involves 4 genes and is affected by 52 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CASP4 CASP5 GSDMD IL1B

Compounds Affecting Non-canonical inflammasome activation

#	Compound	Targets Hit	Studies
1	Disulfiram	—	297
2	felbinac	—	31
3	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
4	Budesonide	—	1,000
5	Hydrocortisone	—	299
6	Prednisolone	—	1,000
7	alsterpaullone	—	12
8	Anisomycin	—	247
9	Antipyrine	—	299
10	Astemizole Antihistamine drug now withdrawn from	—	280
11	Beclomethasone	—	300
12	Betamethasone	—	299
13	Biotin	—	297
14	Bisphenol A-Glycidyl Methacrylate	—	197
15	Carbazilquinone	—	48
16	cardamonin	—	180
17	Chlorhexidine	—	299
18	cycloheximide	—	300
19	Dichlororibofuranosylbenzimidazole	—	26
20	Diethylnitrosamine	—	300
21	Digitoxin	—	300
22	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
23	Digoxin	—	299
24	Dinitrochlorobenzene	—	300
25	Ethidium	—	300
26	Fluocinolone Acetonide	—	295
27	Fluorometholone	—	299
28	Chlorophyll Binding Proteins	—	300
29	Harmaline	—	300
30	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
31	Hydrocortisone	—	298
32	kenpaullone	—	8
33	Lanatosides Glycosides from DIGITALIS lanata leaf. Lanatoside C has actions similar to DIGOXIN. Mixtures of lanatosides A, B, and C have also been used. (From Martindale,	—	115
34	Levodopa	—	297
35	lidoflazine	—	278
36	Melengestrol Acetate	—	300
37	Mometasone Furoate	—	292
38	Nicardipine	—	94
39	Niclosamide	—	299
40	Nisoldipine	—	297
41	Masoprocol	—	300
42	Nortriptyline	—	28
43	Oxyphenbutazone	—	300
44	sp600125	—	117
45	Spironolactone	—	298
46	streptonigrin	—	299
47	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
48	Testosterone Propionate	—	300
49	triflupromazine hydrochloride	—	12
50	Tubercidin	—	300

About the Non-canonical inflammasome activation Pathway

The Non-canonical inflammasome activation pathway is catalogued in Reactome (ID: R-HSA-9686114) and involves 4 genes. In the BiohacksAI corpus, 52 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CASP4, CASP5, GSDMD, IL1B.