A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
Spironolactone has been studied across 22 research domains including ❤️ Cardiovascular, 🫘 Kidney, ✨ Skin & Hair, 🔬 Oncology, 🧬 Hormones. The primary research focus is ❤️ Cardiovascular with 34% of studies addressing this area.
The following compounds share molecular targets with Spironolactone, based on binding affinity data from BindingDB and ChEMBL. Sorted by shared target overlap.
This evidence profile for Spironolactone is generated deterministically from 298 PubMed-indexed studies. All data is corpus-verified with Merkle proofs. BiohacksAI does not provide medical advice. Always consult a healthcare professional before starting any supplement regimen.
Data source: PubMed/MEDLINE (NLM). Corpus version: current. Patent pending (EVE-PAT-2026-001). © 2026 Organiq Sweden AB.