Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function

Q: What compounds affect the Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function pathway?

63 compounds in the BiohacksAI corpus have documented interactions with genes in the Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function pathway (Reactome ID: R-HSA-9704331). These compounds target 9 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-97043319 genes63 compounds

The Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function pathway (Reactome ID: R-HSA-9704331) involves 9 genes and is affected by 63 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ATM BARD1 BLM BRCA1 DNA2 RAD51 RBBP8 SEM1 WRN

Compounds Affecting Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function

#	Compound	Targets Hit	Studies
1	Methotrexate	—	289
2	Astemizole Antihistamine drug now withdrawn from	—	280
3	Azacitidine	—	298
4	Azacitidine	—	300
5	Calcimycin	—	216
6	Chlorhexidine	—	299
7	Ciclopirox	—	88
8	Colchicine	—	300
9	colchine	—	2
10	cycloheximide	—	300
11	Cytarabine	—	297
12	Demecolcine	—	246
13	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
14	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
15	dihydrorotenone	—	13
16	Fluspirilene	—	74
17	gedunin	—	54
18	Hexachlorophene	—	300
19	lidoflazine	—	278
20	Melphalan	—	300
21	Niclosamide	—	299
22	Nocodazole Nocodazole is	—	215
23	paxilline	—	42
24	Podophyllotoxin	—	14
25	rafoxanide	—	172
26	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
27	Trifluridine	—	295
28	Tubercidin	—	300
29	vinblastine sulfate	—	81
30	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
31	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
32	Methylene Blue	—	200
33	Levodopa	—	297
34	streptonigrin	—	299
35	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
36	Resveratrol	—	298
37	calycosin	—	300
38	Semustine 4-Methyl derivative of LOMUSTINE; (CCNU).	—	97
39	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	—	299
40	Aurintricarboxylic Acid	—	184
41	Daunorubicin	—	298
42	Quercetin	—	300
43	Estramustine	—	300
44	Idarubicin	—	299
45	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
46	DEAD-box RNA Helicases	—	169
47	Thioctic Acid	—	298
48	Rosmarinic Acid	—	300
49	Dihydroxyphenylalanine	—	300
50	Vitamin K 3	—	300

About the Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Pathway

The Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function pathway is catalogued in Reactome (ID: R-HSA-9704331) and involves 9 genes. In the BiohacksAI corpus, 63 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ATM, BARD1, BLM, BRCA1, DNA2.