B

BiohacksAI

Evidence-Based Biohacking

Patent Pending

Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function

REACTOME PATHWAY
Reactome: R-HSA-97046469 genes63 compounds

The Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function pathway (Reactome ID: R-HSA-9704646) involves 9 genes and is affected by 63 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ATMBARD1BLMBRCA1DNA2RAD51RBBP8SEM1WRN

Compounds Affecting Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function

#CompoundTargets HitStudies
1Methotrexate—289
2Astemizole Antihistamine drug now withdrawn from—280
3Azacitidine—298
4Azacitidine—300
5Calcimycin—216
6Chlorhexidine—299
7Ciclopirox—88
8Colchicine—300
9colchine—2
10cycloheximide—300
11Cytarabine—297
12Demecolcine—246
13Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.—300
14Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.—300
15dihydrorotenone—13
16Fluspirilene—74
17gedunin—54
18Hexachlorophene—300
19lidoflazine—278
20Melphalan—300
21Niclosamide—299
22Nocodazole Nocodazole is—215
23paxilline—42
24Podophyllotoxin—14
25rafoxanide—172
26Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.—300
27Trifluridine—295
28Tubercidin—300
29vinblastine sulfate—81
30Luteolin 5,7,3',4'-tetrahydroxy-flavone,—150
31myricetin-3-O-galactopyranoside [Supplementary Concept]—300
32Methylene Blue—200
33Levodopa—297
34streptonigrin—299
35Apigenin 5,7,4'-trihydroxy-flavone,—300
36Resveratrol—298
37calycosin—300
38Semustine 4-Methyl derivative of LOMUSTINE; (CCNU).—97
39Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against—299
40Aurintricarboxylic Acid—184
41Daunorubicin—298
42Quercetin—300
43Estramustine—300
44Idarubicin—299
45juglone hydroxylase [Supplementary Concept] catalyzes—279
46DEAD-box RNA Helicases—169
47Thioctic Acid—298
48Rosmarinic Acid—300
49Dihydroxyphenylalanine—300
50Vitamin K 3—300

About the Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Pathway

The Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function pathway is catalogued in Reactome (ID: R-HSA-9704646) and involves 9 genes. In the BiohacksAI corpus, 63 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ATM, BARD1, BLM, BRCA1, DNA2.