What compounds affect the Azathioprine ADME pathway?

44 compounds in the BiohacksAI corpus have documented interactions with genes in the Azathioprine ADME pathway (Reactome ID: R-HSA-9748787). These compounds target 9 genes within this pathway.

What genes are in the Azathioprine ADME pathway?

The Azathioprine ADME pathway involves 9 genes. Key genes include: ABCC4, ABCC5, HPRT1, IMPDH1, IMPDH2, SLC28A2, SLC28A3, SLC29A1, XDH.

Azathioprine ADME

REACTOME PATHWAY

Reactome: R-HSA-97487879 genes44 compounds

The Azathioprine ADME pathway (Reactome ID: R-HSA-9748787) involves 9 genes and is affected by 44 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABCC4 ABCC5 HPRT1 IMPDH1 IMPDH2 SLC28A2 SLC28A3 SLC29A1 XDH

Compounds Affecting Azathioprine ADME

#	Compound	Targets Hit	Studies
1	Adenosine	—	298
2	Inosine Monophosphate Inosine 5'-Monophosphate.	—	299
3	Cyclic GMP Guanosine cyclic 3',5'-(hydrogen phosphate).	—	300
4	Febuxostat	—	297
5	Uridine	—	300
6	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
7	Alprostadil	—	297
8	Dehydroepiandrosterone Sulfate	—	300
9	Rimonabant	—	300
10	amlexanox	—	96
11	Camptothecin	—	300
12	cefaclor	—	299
13	Cefamandole Semisynthetic wide-spectrum cephalosporin with prolonged action, probably due to beta-lactamase resistance. It is used also as	—	300
14	Cefmetazole	—	300
15	Cefoperazone Semisynthetic broad-spectrum cephalosporin with	—	300
16	Cefoxitin	—	300
17	Ceftriaxone	—	299
18	cefuroxime	—	299
19	Cephradine	—	298
20	Dinoprostone	—	296
21	Doxazosin	—	24
22	felbinac	—	31
23	Tubocurarine	—	300
24	Quercetin	—	300
25	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
26	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
27	chrysin	—	300
28	Oxypurinol	—	300
29	fisetin	—	78
30	Genistein	—	300
31	Kaempferols	—	300
32	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
33	Hesperidin	—	300
34	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
35	dilazep	—	300
36	lidoflazine	—	278
37	Ticagrelor	—	299
38	Sirolimus	—	300
39	Fidaxomicin	—	295
40	Gemcitabine	—	300
41	Papaverine	—	299
42	Rifaximin	—	298
43	guanine	—	299
44	Guanosine Monophosphate	—	300

About the Azathioprine ADME Pathway

The Azathioprine ADME pathway is catalogued in Reactome (ID: R-HSA-9748787) and involves 9 genes. In the BiohacksAI corpus, 44 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABCC4, ABCC5, HPRT1, IMPDH1, IMPDH2.