Antigen processing: Ubiquitination & Proteasome degradation

Q: What compounds affect the Antigen processing: Ubiquitination & Proteasome degradation pathway?

37 compounds in the BiohacksAI corpus have documented interactions with genes in the Antigen processing: Ubiquitination & Proteasome degradation pathway (Reactome ID: R-HSA-983168). These compounds target 41 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-98316841 genes37 compounds

The Antigen processing: Ubiquitination & Proteasome degradation pathway (Reactome ID: R-HSA-983168) involves 41 genes and is affected by 37 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 CUL1 NPEPPS PRKN PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2+11 more

Compounds Affecting Antigen processing: Ubiquitination & Proteasome degradation

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	candesartan cilexetil [Supplementary Concept]	—	300
4	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
5	Genistein	—	300
6	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
7	ninhydrin	—	300
8	Disulfiram	—	297
9	4-Hydroxybenzoate-3-Monooxygenase	—	300
10	chrysin	—	300
11	egcg	—	300
12	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
13	Quercetin	—	300
14	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
15	naringin	—	300
16	Chlorhexidine	—	299
17	Perphenazine	—	297
18	Sphingosine	—	300
19	Resveratrol	—	298
20	Sertraline	—	1,000
21	Astemizole Antihistamine drug now withdrawn from	—	280
22	Canrenone	—	300
23	Thioridazine	—	35
24	kenpaullone	—	8
25	amn082	—	29
26	Hexachlorophene	—	300
27	Medroxyprogesterone Acetate	—	299
28	Nitrendipine	—	299
29	Amlodipine	—	1,000
30	piceatannol	—	300
31	sp600125	—	117
32	Cetylpyridinium Cationic bactericidal surfactant used as	—	300
33	Pioglitazone	—	297
34	Harmaline	—	300
35	Gliotoxin	—	300
36	Podophyllotoxin	—	14
37	Puromycin	—	300

About the Antigen processing: Ubiquitination & Proteasome degradation Pathway

The Antigen processing: Ubiquitination & Proteasome degradation pathway is catalogued in Reactome (ID: R-HSA-983168) and involves 41 genes. In the BiohacksAI corpus, 37 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, CUL1, NPEPPS, PRKN, PSMA1.