Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy

Q: What compounds affect the Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy pathway?

46 compounds in the BiohacksAI corpus have documented interactions with genes in the Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy pathway (Reactome ID: R-HSA-9857377). These compounds target 2 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-98573772 genes46 compounds

The Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy pathway (Reactome ID: R-HSA-9857377) involves 2 genes and is affected by 46 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ATP6V1B2 MITF

Compounds Affecting Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy

#	Compound	Targets Hit	Studies
1	Cefdinir	—	298
2	Ethidium	—	300
3	Oxytetracycline	—	300
4	egcg	—	300
5	colchine	—	2
6	Anthralin	—	299
7	Aurintricarboxylic Acid	—	184
8	Biotin	—	297
9	Rolitetracycline	—	166
10	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
11	Rutin	—	300
12	cycloheximide	—	300
13	Oxyphenbutazone	—	300
14	Topotecan	—	300
15	Methylene Blue	—	200
16	Rosmarinic Acid	—	300
17	Anisomycin	—	247
18	Astemizole Antihistamine drug now withdrawn from	—	280
19	Azacitidine	—	298
20	Azacitidine	—	300
21	Bortezomib	—	300
22	Calcimycin	—	216
23	Camptothecin	—	300
24	Carmine Coloring matter from	—	300
25	celastrol	—	300
26	Ciclopirox	—	88
27	clofilium tosylate	—	4
28	Demecolcine	—	246
29	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
30	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
31	Digoxin	—	299
32	Droxidopa	—	202
33	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
34	Lanatosides Glycosides from DIGITALIS lanata leaf. Lanatoside C has actions similar to DIGOXIN. Mixtures of lanatosides A, B, and C have also been used. (From Martindale,	—	115
35	Levodopa	—	297
36	Niclosamide	—	299
37	Nocodazole Nocodazole is	—	215
38	pictilisib	—	25
39	Podophyllotoxin	—	14
40	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
41	torin 1	—	10
42	tyrphostin 9	—	2
43	vinblastine sulfate	—	81
44	Vincristine	—	299
45	Vorinostat	—	299
46	Enoxacin	—	299

About the Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy Pathway

The Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy pathway is catalogued in Reactome (ID: R-HSA-9857377) and involves 2 genes. In the BiohacksAI corpus, 46 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ATP6V1B2, MITF.