Regulation of pyruvate metabolism
REACTOME PATHWAYThe Regulation of pyruvate metabolism pathway (Reactome ID: R-HSA-9861718) involves 3 genes and is affected by 17 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Regulation of pyruvate metabolism
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | fisetin | — | 78 |
| 2 | Apigenin 5,7,4'-trihydroxy-flavone, | — | 300 |
| 3 | myricetin-3-O-galactopyranoside [Supplementary Concept] | — | 300 |
| 4 | alphitonin [Supplementary Concept] from | — | 300 |
| 5 | Sirolimus | — | 300 |
| 6 | Spermidine | — | 241 |
| 7 | Catechin | — | 300 |
| 8 | Niclosamide | — | 299 |
| 9 | pd98059 | — | 7 |
| 10 | Pseudoephedrine | — | 298 |
| 11 | Suramin | — | 300 |
| 12 | egcg | — | 300 |
| 13 | Rutin | — | 300 |
| 14 | Oxaprozin | — | 181 |
| 15 | Pioglitazone | — | 297 |
| 16 | streptonigrin | — | 299 |
| 17 | chrysin | — | 300 |
About the Regulation of pyruvate metabolism Pathway
The Regulation of pyruvate metabolism pathway is catalogued in Reactome (ID: R-HSA-9861718) and involves 3 genes. In the BiohacksAI corpus, 17 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include DLD, PDK1, PKM.