Modulation of host responses by IFN-stimulated genes
REACTOME PATHWAYThe Modulation of host responses by IFN-stimulated genes pathway (Reactome ID: R-HSA-9909505) involves 6 genes and is affected by 19 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Modulation of host responses by IFN-stimulated genes
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | chicoric acid | — | 117 |
| 2 | alsterpaullone | — | 12 |
| 3 | Aurintricarboxylic Acid | — | 184 |
| 4 | Crizotinib | — | 298 |
| 5 | sp600125 | — | 117 |
| 6 | fluoranthene | — | 300 |
| 7 | Ethoxyquin Antioxidant; also | — | 180 |
| 8 | Methylcholanthrene | — | 300 |
| 9 | Mometasone Furoate | — | 292 |
| 10 | Masoprocol | — | 300 |
| 11 | aniracetam | — | 110 |
| 12 | 2-Chloroadenosine 2-Chloroadenosine. | — | 300 |
| 13 | Camptothecin | — | 300 |
| 14 | Hexachlorophene | — | 300 |
| 15 | Adenosine Diphosphate Adenosine 5'-(trihydrogen diphosphate). | — | 300 |
| 16 | Ergosterol | — | 300 |
| 17 | Sirolimus | — | 300 |
| 18 | Everolimus | — | 297 |
| 19 | glaucarubinone | — | 10 |
About the Modulation of host responses by IFN-stimulated genes Pathway
The Modulation of host responses by IFN-stimulated genes pathway is catalogued in Reactome (ID: R-HSA-9909505) and involves 6 genes. In the BiohacksAI corpus, 19 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ATF6, CHUK, EIF2AK3, FKBP5, HSPA5.