GSK3B-mediated proteasomal degradation of PD-L1(CD274)

Q: What compounds affect the GSK3B-mediated proteasomal degradation of PD-L1(CD274) pathway?

36 compounds in the BiohacksAI corpus have documented interactions with genes in the GSK3B-mediated proteasomal degradation of PD-L1(CD274) pathway (Reactome ID: R-HSA-9929356). These compounds target 37 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-992935637 genes36 compounds

The GSK3B-mediated proteasomal degradation of PD-L1(CD274) pathway (Reactome ID: R-HSA-9929356) involves 37 genes and is affected by 36 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 COPS5 CUL1 GSK3B NEK2 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14+7 more

Compounds Affecting GSK3B-mediated proteasomal degradation of PD-L1(CD274)

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	Quercetin	—	300
4	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
5	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
6	chrysin	—	300
7	egcg	—	300
8	sp600125	—	117
9	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
10	ninhydrin	—	300
11	alsterpaullone	—	12
12	kenpaullone	—	8
13	indirubin	—	300
14	Kaempferols	—	300
15	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
16	Lithium Chloride	—	300
17	fisetin	—	78
18	ly294002	—	11
19	Sorafenib	—	300
20	Rutin	—	300
21	Ursolic Acid	—	300
22	Oleanolic Acid	—	300
23	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
24	Disulfiram	—	297
25	4-Hydroxybenzoate-3-Monooxygenase	—	300
26	Genistein	—	300
27	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
28	DEAD-box RNA Helicases	—	169
29	Thioctic Acid	—	298
30	Sphingosine	—	300
31	Thioctic Acid	—	300
32	Vemurafenib	—	298
33	candesartan cilexetil [Supplementary Concept]	—	300
34	Cetylpyridinium Cationic bactericidal surfactant used as	—	300
35	Pioglitazone	—	297
36	Harmaline	—	300

About the GSK3B-mediated proteasomal degradation of PD-L1(CD274) Pathway

The GSK3B-mediated proteasomal degradation of PD-L1(CD274) pathway is catalogued in Reactome (ID: R-HSA-9929356) and involves 37 genes. In the BiohacksAI corpus, 36 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, COPS5, CUL1, GSK3B, NEK2.