Question 1

What compounds affect the SPOP-mediated proteasomal degradation of PD-L1(CD274) pathway?

Accepted Answer

29 compounds in the BiohacksAI corpus have documented interactions with genes in the SPOP-mediated proteasomal degradation of PD-L1(CD274) pathway (Reactome ID: R-HSA-9929491). These compounds target 38 genes within this pathway.

Question 2

What genes are in the SPOP-mediated proteasomal degradation of PD-L1(CD274) pathway?

Accepted Answer

The SPOP-mediated proteasomal degradation of PD-L1(CD274) pathway involves 38 genes. Key genes include: ADRM1, CDK4, CSNK2A1, CSNK2A2, CSNK2B, PSMA1, PSMA2, PSMA3, PSMA4, PSMA5.

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
4	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
5	Quercetin	—	300
6	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
7	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
8	chrysin	—	300
9	fisetin	—	78
10	Kaempferols	—	300
11	Vanillic Acid	—	300
12	ly294002	—	11
13	Dichlororibofuranosylbenzimidazole	—	26
14	Adenylyl Imidodiphosphate 5'-Adenylic acid, monoanhydride with imidodiphosphoric acid.	—	300
15	alsterpaullone	—	12
16	kenpaullone	—	8
17	sp600125	—	117
18	pictilisib	—	25
19	Axitinib	—	298
20	Disulfiram	—	297
21	4-Hydroxybenzoate-3-Monooxygenase	—	300
22	egcg	—	300
23	Genistein	—	300
24	Pioglitazone	—	297
25	Harmaline	—	300
26	Idarubicin	—	299
27	Masoprocol	—	300
28	indirubin	—	300
29	ninhydrin	—	300

BiohacksAI

SPOP-mediated proteasomal degradation of PD-L1(CD274)

Genes in this Pathway

Compounds Affecting SPOP-mediated proteasomal degradation of PD-L1(CD274)

About the SPOP-mediated proteasomal degradation of PD-L1(CD274) Pathway