What compounds affect the CASP5-mediated substrate cleavage pathway?

52 compounds in the BiohacksAI corpus have documented interactions with genes in the CASP5-mediated substrate cleavage pathway (Reactome ID: R-HSA-9960525). These compounds target 3 genes within this pathway.

What genes are in the CASP5-mediated substrate cleavage pathway?

The CASP5-mediated substrate cleavage pathway involves 3 genes. Key genes include: CASP5, GSDMD, IL1B.

CASP5-mediated substrate cleavage

REACTOME PATHWAY

Reactome: R-HSA-99605253 genes52 compounds

The CASP5-mediated substrate cleavage pathway (Reactome ID: R-HSA-9960525) involves 3 genes and is affected by 52 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CASP5 GSDMD IL1B

Compounds Affecting CASP5-mediated substrate cleavage

#	Compound	Targets Hit	Studies
1	Disulfiram	—	297
2	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
3	Budesonide	—	1,000
4	Hydrocortisone	—	299
5	Prednisolone	—	1,000
6	alsterpaullone	—	12
7	Anisomycin	—	247
8	Antipyrine	—	299
9	Astemizole Antihistamine drug now withdrawn from	—	280
10	Beclomethasone	—	300
11	Betamethasone	—	299
12	Biotin	—	297
13	Bisphenol A-Glycidyl Methacrylate	—	197
14	Carbazilquinone	—	48
15	cardamonin	—	180
16	Chlorhexidine	—	299
17	cycloheximide	—	300
18	Dichlororibofuranosylbenzimidazole	—	26
19	Diethylnitrosamine	—	300
20	Digitoxin	—	300
21	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
22	Digoxin	—	299
23	Dinitrochlorobenzene	—	300
24	Ethidium	—	300
25	Fluocinolone Acetonide	—	295
26	Fluorometholone	—	299
27	Chlorophyll Binding Proteins	—	300
28	Harmaline	—	300
29	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
30	Hydrocortisone	—	298
31	kenpaullone	—	8
32	Lanatosides Glycosides from DIGITALIS lanata leaf. Lanatoside C has actions similar to DIGOXIN. Mixtures of lanatosides A, B, and C have also been used. (From Martindale,	—	115
33	Levodopa	—	297
34	lidoflazine	—	278
35	Melengestrol Acetate	—	300
36	Mometasone Furoate	—	292
37	Nicardipine	—	94
38	Niclosamide	—	299
39	Nisoldipine	—	297
40	Masoprocol	—	300
41	Nortriptyline	—	28
42	Oxyphenbutazone	—	300
43	sp600125	—	117
44	Spironolactone	—	298
45	streptonigrin	—	299
46	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
47	Testosterone Propionate	—	300
48	triflupromazine hydrochloride	—	12
49	Tubercidin	—	300
50	tyrphostin 9	—	2

About the CASP5-mediated substrate cleavage Pathway

The CASP5-mediated substrate cleavage pathway is catalogued in Reactome (ID: R-HSA-9960525) and involves 3 genes. In the BiohacksAI corpus, 52 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CASP5, GSDMD, IL1B.