What compounds target CYP2C9?

BiohacksAI has identified 295 compounds that interact with CYP2C9 (cytochrome P450 family 2 subfamily C member 9). Top compounds include: Sulfaphenazole, Disulfiram, Clotrimazole, Glyburide, Phenytoin. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is CYP2C9 (cytochrome P450 family)?

CYP2C9 is cytochrome P450 family 2 subfamily C member 9. It is a molecular target for 295 compounds documented in PubMed bioassay data. NCBI Gene ID: 1559.

CYP2C9

MOLECULAR TARGET

cytochrome P450 family 2 subfamily C member 9

NCBI Gene: 1559295 compounds

CYP2C9 (cytochrome P450 family 2 subfamily C member 9) is targeted by 295 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting CYP2C9

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Sulfaphenazole	4.11	60
2	Disulfiram	2.56	12
3	Clotrimazole	2.48	11
4	Glyburide	2.40	10
5	Phenytoin	2.40	10
6	Gemfibrozil	2.30	9
7	Levonorgestrel	2.30	9
8	Norgestrel	2.30	9
9	Celecoxib	2.20	8
10	Finasteride	2.20	8
11	Phenylbutazone	2.20	8
12	Pueraria	2.08	7
13	Quercetin	2.08	7
14	Chlorhexidine	2.08	7
15	Danazol	2.08	7
16	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	2.08	7
17	Fenofibrate	2.08	7
18	Flutamide	2.08	7
19	Fulvestrant	2.08	7
20	Hexachlorophene	2.08	7
21	Loratadine	2.08	7
22	Meloxicam	2.08	7
23	Mestranol	2.08	7
24	Methoxsalen	2.08	7
25	Niclosamide	2.08	7
26	Rotenone	2.08	7
27	Budesonide	1.95	6
28	Dehydroepiandrosterone	1.95	6
29	Progesterone	1.95	6
30	Acetohexamide	1.95	6
31	Dehydroepiandrosterone	1.95	6
32	Edaravone	1.95	6
33	Ethoxyquin Antioxidant; also	1.95	6
34	Nisoldipine	1.95	6
35	Piperonyl Butoxide	1.95	6
36	Testosterone Propionate	1.95	6
37	Tolazamide	1.95	6
38	Tolbutamide	1.95	6
39	Troglitazone	1.95	6
40	Apigenin 5,7,4'-trihydroxy-flavone,	1.79	5
41	Thyroxine	1.79	5
42	Methylene Blue	1.79	5
43	myricetin-3-O-galactopyranoside [Supplementary Concept]	1.79	5
44	Vitamin	1.79	5
45	17 alpha-Hydroxyprogesterone Caproate Hydroxyprogesterone derivative that acts as	1.79	5
46	alpha-Linolenic Acid	1.79	5
47	Anastrozole	1.79	5
48	Chlormadinone Acetate	1.79	5
49	Chlorpropamide	1.79	5
50	Cimetidine	1.79	5

Showing top 50 of 295 compounds. Use the BiohacksAI search to explore all CYP2C9 modulators.

About CYP2C9 as a Drug Target

CYP2C9 (cytochrome P450 family 2 subfamily C member 9) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 295 compounds with documented CYP2C9 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

CYP2C9 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.