GPBAR1
MOLECULAR TARGETG protein-coupled bile acid receptor 1
GPBAR1 (G protein-coupled bile acid receptor 1) is targeted by 23 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).
Compounds Targeting GPBAR1
Ranked by bioassay confidence score (PubChem active assay count × evidence quality).
| # | Compound | Confidence | Active Assays |
|---|---|---|---|
| 1 | obeticholic acid [Supplementary Concept] | 2.71 | 14 |
| 2 | Lithocholic Acid | 2.48 | 11 |
| 3 | Chenodeoxycholic Acid | 2.40 | 10 |
| 4 | Cholic Acid | 2.20 | 8 |
| 5 | Taurodeoxycholic Acid | 1.95 | 6 |
| 6 | Taurolithocholic Acid | 1.95 | 6 |
| 7 | Deoxycholic Acid | 1.39 | 3 |
| 8 | Oleanolic Acid | 1.10 | 2 |
| 9 | Taurochenodeoxycholic Acid | 1.10 | 2 |
| 10 | Ursodeoxycholic Acid | 1.10 | 2 |
| 11 | Dehydroepiandrosterone | 0.69 | 1 |
| 12 | Prednisolone | 0.69 | 1 |
| 13 | Progesterone | 0.69 | 1 |
| 14 | Ursolic Acid | 0.69 | 1 |
| 15 | 5-alpha-Dihydroprogesterone | 0.69 | 1 |
| 16 | Androsterone | 0.69 | 1 |
| 17 | Dehydroepiandrosterone | 0.69 | 1 |
| 18 | Dihydrotestosterone | 0.69 | 1 |
| 19 | Etiocholanolone | 0.69 | 1 |
| 20 | Glycochenodeoxycholic Acid | 0.69 | 1 |
| 21 | Glycodeoxycholic Acid | 0.69 | 1 |
| 22 | Pregnanediol | 0.69 | 1 |
| 23 | Taurocholic Acid | 0.69 | 1 |
About GPBAR1 as a Drug Target
GPBAR1 (G protein-coupled bile acid receptor 1) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 23 compounds with documented GPBAR1 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.
GPBAR1 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.