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5 Alpha Dihydroprogesterone

A biologically active 5-alpha-reduced metabolite of plasma PROGESTERONE. It is the immediate precursor of 5-alpha-pregnan-3-alpha-ol-20-one (ALLOPREGNANOLONE), a neuroactive steroid that binds with GABA(A) RECEPTOR.

85+ PubMed studies analyzed · 2 RCTs · Evidence Score: 44.4

Research Domains

5 Alpha Dihydroprogesterone has been studied across 21 research domains including 🧬 Hormones, 🧘 Stress & Anxiety, 💪 Strength & Power, 👁️ Vision & Eye, 🧠 Focus & Attention. The primary research focus is 🧬 Hormones with 85% of studies addressing this area.

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This evidence profile for 5 Alpha Dihydroprogesterone is generated deterministically from 85 PubMed-indexed studies. All data is corpus-verified with Merkle proofs. BiohacksAI does not provide medical advice. Always consult a healthcare professional before starting any supplement regimen.

Data source: PubMed/MEDLINE (NLM). Corpus version: current. Patent pending (EVE-PAT-2026-001). © 2026 Organiq Sweden AB.