What compounds target MKNK2?

BiohacksAI has identified 40 compounds that interact with MKNK2 (MAPK interacting serine/threonine kinase 2). Top compounds include: gefitinib, erlotinib, tofacitinib, alvocidib, foretinib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is MKNK2 (MAPK interacting serine/threonine)?

MKNK2 is MAPK interacting serine/threonine kinase 2. It is a molecular target for 40 compounds documented in PubMed bioassay data. UniProt ID: Q9HBH9. NCBI Gene ID: 2872.

MKNK2

MOLECULAR TARGET

MAPK interacting serine/threonine kinase 2

UniProt: Q9HBH9 NCBI Gene: 287240 compounds

MKNK2 (MAPK interacting serine/threonine kinase 2) is targeted by 40 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting MKNK2

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	gefitinib	5.67	290
2	erlotinib	5.55	256
3	tofacitinib	4.65	104
4	alvocidib	4.52	91
5	foretinib	4.34	76
6	tozasertib	4.33	75
7	vandetanib	4.30	73
8	ruxolitinib	4.23	68
9	ceritinib	4.19	65
10	doramapimod	4.06	57
11	quizartinib	3.99	53
12	midostaurin	3.85	46
13	canertinib	3.53	33
14	bms 387032	3.47	31
15	tae 684	3.43	30
16	fedratinib	3.40	29
17	linifanib	3.33	27
18	mln 8054	3.33	27
19	hispidulin	3.33	27
20	sp 600125	3.22	24
21	lestaurtinib	3.04	20
22	genkwanin	3.04	20
23	defosbarasertib	2.89	17
24	r 406	2.83	16
25	kw 2449	2.64	13
26	ast 487	2.56	12
27	cp 724714	2.56	12
28	merestinib	2.48	11
29	Sorafenib	2.20	8
30	su 014813	2.20	8
31	rebastinib	2.20	8
32	tg100 115	2.08	7
33	tomivosertib	2.08	7
34	tinodasertib	1.95	6
35	aigialomycin d	1.79	5
36	sp600125	1.10	2
37	Apigenin 5,7,4'-trihydroxy-flavone,	0.69	1
38	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	0.69	1
39	Afatinib	0.69	1
40	hydroxyfasudil [Supplementary Concept]	0.69	1

About MKNK2 as a Drug Target

MKNK2 (MAPK interacting serine/threonine kinase 2) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 40 compounds with documented MKNK2 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

MKNK2 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.