What compounds target NQO2?

BiohacksAI has identified 42 compounds that interact with NQO2 (N-ribosyldihydronicotinamide:quinone dehydrogenase 2). Top compounds include: imatinib, prazosin, osimertinib, primaquine, nilotinib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

NQO2

Q: What is NQO2 (N-ribosyldihydronicotinamide:quinone dehydrogenase 2)?

NQO2 is N-ribosyldihydronicotinamide:quinone dehydrogenase 2. It is a molecular target for 42 compounds documented in PubMed bioassay data. UniProt ID: P16083. NCBI Gene ID: 4835.

MOLECULAR TARGET

N-ribosyldihydronicotinamide:quinone dehydrogenase 2

UniProt: P16083 NCBI Gene: 483542 compounds

NQO2 (N-ribosyldihydronicotinamide:quinone dehydrogenase 2) is targeted by 42 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting NQO2

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	imatinib	5.47	236
2	prazosin	5.15	172
3	osimertinib	5.03	152
4	primaquine	4.91	135
5	nilotinib	4.17	64
6	furamidine	3.99	53
7	molibresib	3.81	44
8	fasudil	3.66	38
9	trismethoxyresveratrol	3.56	34
10	fedratinib	3.40	29
11	gilteritinib	3.40	29
12	aminacrine	3.22	24
13	dovitinib	3.09	21
14	dabigatran	3.09	21
15	lestaurtinib	3.04	20
16	pacritinib	3.04	20
17	lenvatinib	3.04	20
18	k 252a	2.83	16
19	masitinib	2.77	15
20	crenolanib	2.71	14
21	jnj 38877605	2.71	14
22	kw 2449	2.64	13
23	e 3435 tetramethoxystilbene	2.64	13
24	Resveratrol	2.48	11
25	iodomelatonin	2.48	11
26	ripasudil	2.40	10
27	sgx 523	2.30	9
28	rigosertib	2.30	9
29	binimetinib	2.30	9
30	tepotinib	2.20	8
31	cyc 116	2.08	7
32	asp 3026	2.08	7
33	amg 900	2.08	7
34	mk 2461	2.08	7
35	osi 027	2.08	7
36	Melatonin	1.95	6
37	bafetinib	1.95	6
38	tucatinib	1.95	6
39	talmapimod	1.95	6
40	pterostilbene	0.69	1
41	hydroxyfasudil [Supplementary Concept]	0.69	1
42	pictilisib	0.69	1

About NQO2 as a Drug Target

NQO2 (N-ribosyldihydronicotinamide:quinone dehydrogenase 2) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 42 compounds with documented NQO2 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

NQO2 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.