PIK3CA
MOLECULAR TARGETphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) is targeted by 46 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).
Compounds Targeting PIK3CA
Ranked by bioassay confidence score (PubChem active assay count × evidence quality).
| # | Compound | Confidence | Active Assays |
|---|---|---|---|
| 1 | epigalocatechin gallate | 5.40 | 220 |
| 2 | ly 294002 | 4.84 | 126 |
| 3 | dactolisib | 4.25 | 69 |
| 4 | pi 103 | 4.17 | 64 |
| 5 | idelalisib | 4.13 | 61 |
| 6 | bi 2536 | 4.01 | 54 |
| 7 | romidepsin | 3.95 | 51 |
| 8 | midostaurin | 3.85 | 46 |
| 9 | catechol | 3.76 | 42 |
| 10 | zstk 474 | 3.56 | 34 |
| 11 | cgs 15943 | 3.47 | 31 |
| 12 | fedratinib | 3.40 | 29 |
| 13 | buparlisib | 3.40 | 29 |
| 14 | omipalisib | 3.14 | 22 |
| 15 | lestaurtinib | 3.04 | 20 |
| 16 | quisinostat | 2.94 | 18 |
| 17 | ku 55933 | 2.94 | 18 |
| 18 | duvelisib | 2.94 | 18 |
| 19 | fimepinostat | 2.89 | 17 |
| 20 | azd 8055 | 2.89 | 17 |
| 21 | apitolisib | 2.71 | 14 |
| 22 | pf 04691502 | 2.64 | 13 |
| 23 | sapanisertib | 2.64 | 13 |
| 24 | gedatolisib | 2.56 | 12 |
| 25 | vistusertib | 2.48 | 11 |
| 26 | torin1 | 2.40 | 10 |
| 27 | copanlisib | 2.40 | 10 |
| 28 | azd 6482 | 2.30 | 9 |
| 29 | bimiralisib | 2.30 | 9 |
| 30 | azd 7648 | 2.30 | 9 |
| 31 | vs 5584 | 2.30 | 9 |
| 32 | bgt 226 free base | 2.20 | 8 |
| 33 | ku 0063794 | 2.20 | 8 |
| 34 | tg100 115 | 2.08 | 7 |
| 35 | osi 027 | 2.08 | 7 |
| 36 | voxtalisib | 2.08 | 7 |
| 37 | gsk 1059615 | 1.95 | 6 |
| 38 | pilaralisib | 1.95 | 6 |
| 39 | rg 7603 | 1.95 | 6 |
| 40 | azd 8186 | 1.79 | 5 |
| 41 | eganelisib | 1.79 | 5 |
| 42 | ly294002 | 1.61 | 4 |
| 43 | pictilisib | 1.10 | 2 |
| 44 | Sirolimus | 0.69 | 1 |
| 45 | alpelisib | 0.69 | 1 |
| 46 | Wortmannin | 0.69 | 1 |
About PIK3CA as a Drug Target
PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 46 compounds with documented PIK3CA interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.
PIK3CA inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.