What compounds target SNCA?

BiohacksAI has identified 23 compounds that interact with SNCA (synuclein alpha). Top compounds include: egcg, Genistein, Bortezomib, Calcimycin, celastrol. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is SNCA (synuclein alpha)?

SNCA is synuclein alpha. It is a molecular target for 23 compounds documented in PubMed bioassay data. UniProt ID: P37840. NCBI Gene ID: 6622.

SNCA

MOLECULAR TARGET

synuclein alpha

UniProt: P37840 NCBI Gene: 662223 compounds

SNCA (synuclein alpha) is targeted by 23 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting SNCA

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	egcg	1.39	3
2	Genistein	1.10	2
3	Bortezomib	1.10	2
4	Calcimycin	1.10	2
5	celastrol	1.10	2
6	Hydroxyurea	1.10	2
7	Niacin	1.10	2
8	Masoprocol	1.10	2
9	myricetin-3-O-galactopyranoside [Supplementary Concept]	0.69	1
10	Rosmarinic Acid	0.69	1
11	(N-methyl-C-11)-2-(4-methylamino-phenyl)-6-hydroxybenzothiazole [Supplementary Concept] neutral analog of amyloid-binding thioflavin-T (BTA) that crosses	0.69	1
12	Vitamin	0.69	1
13	Azauridine	0.69	1
14	Ceftriaxone	0.69	1
15	Catechin	0.69	1
16	Vanillic Acid	0.69	1
17	ketoconazole	0.69	1
18	Lithocholic Acid	0.69	1
19	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	0.69	1
20	Pergolide	0.69	1
21	Pramipexole	0.69	1
22	Retinaldehyde	0.69	1
23	Tetracycline	0.69	1

About SNCA as a Drug Target

SNCA (synuclein alpha) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 23 compounds with documented SNCA interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

SNCA inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.