What compounds affect the PI3K Cascade pathway?

29 compounds in the BiohacksAI corpus have documented interactions with genes in the PI3K Cascade pathway (Reactome ID: R-HSA-109704). These compounds target 14 genes within this pathway.

What genes are in the PI3K Cascade pathway?

The PI3K Cascade pathway involves 14 genes. Key genes include: FGF22, FGFR1, FGFR2, FGFR3, FGFR4, FLT3, GRB2, PDE3B, PDPK1, PIK3C3.

PI3K Cascade

REACTOME PATHWAY

Reactome: R-HSA-10970414 genes29 compounds

The PI3K Cascade pathway (Reactome ID: R-HSA-109704) involves 14 genes and is affected by 29 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

FGF22 FGFR1 FGFR2 FGFR3 FGFR4 FLT3 GRB2 PDE3B PDPK1 PIK3C3 PIK3CB PIK3R1 PIK3R2 TLR9

Compounds Affecting PI3K Cascade

#	Compound	Targets Hit	Studies
1	pictilisib	—	25
2	Sorafenib	—	300
3	Axitinib	—	298
4	sp600125	—	117
5	Wortmannin	—	300
6	ly294002	—	11
7	Sirolimus	—	300
8	Dasatinib	—	299
9	Crizotinib	—	298
10	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
11	Quercetin	—	300
12	kenpaullone	—	8
13	alpelisib	—	227
14	torin 1	—	10
15	alsterpaullone	—	12
16	Afatinib	—	297
17	tyrphostin ag 1295	—	1
18	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
19	Kaempferols	—	300
20	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
21	tyrphostin ag 1478	—	4
22	Resveratrol	—	298
23	Cilostazol	—	297
24	Papaverine	—	299
25	Enoximone	—	300
26	Cyclic GMP Guanosine cyclic 3',5'-(hydrogen phosphate).	—	300
27	Acrylamide	—	300
28	Dactinomycin	—	297
29	Oxyphenbutazone	—	300

About the PI3K Cascade Pathway

The PI3K Cascade pathway is catalogued in Reactome (ID: R-HSA-109704) and involves 14 genes. In the BiohacksAI corpus, 29 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include FGF22, FGFR1, FGFR2, FGFR3, FGFR4.