Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template

Q: What compounds affect the Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template pathway?

59 compounds in the BiohacksAI corpus have documented interactions with genes in the Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template pathway (Reactome ID: R-HSA-110313). These compounds target 6 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-1103136 genes59 compounds

The Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template pathway (Reactome ID: R-HSA-110313) involves 6 genes and is affected by 59 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

PCNA POLH POLI POLK USP10 VCP

Compounds Affecting Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template

#	Compound	Targets Hit	Studies
1	Quercetin	—	300
2	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
3	alpha-Linolenic Acid	—	300
4	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
5	Ethidium	—	300
6	gamma-Linolenic Acid	—	300
7	Levodopa	—	297
8	Masoprocol	—	300
9	piceatannol	—	300
10	Cefixime	—	300
11	Diiodotyrosine	—	300
12	Idarubicin	—	299
13	Norepinephrine Precursor of epinephrine that is secreted by	—	298
14	Ampicillin Semi-synthetic derivative of penicillin that functions as	—	294
15	Aurintricarboxylic Acid	—	184
16	Cefotetan	—	299
17	Oxytetracycline	—	300
18	streptonigrin	—	299
19	Carmine Coloring matter from	—	300
20	candesartan cilexetil [Supplementary Concept]	—	300
21	Methyldopa	—	297
22	Demeclocycline	—	5
23	Dithiazanine 3-Ethyl-2-(5-(3-ethyl-2-benzothiazolinylidene)-1,3- pentadienyl)benzothiazolium.	—	135
24	Catechin	—	300
25	Kaempferols	—	300
26	Methotrexate	—	289
27	Hexachlorophene	—	300
28	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
29	Epinephrine	—	299
30	Arachidonic Acid	—	245
31	fisetin	—	78
32	Daunorubicin	—	298
33	DEAD-box RNA Helicases	—	169
34	Thioctic Acid	—	298
35	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
36	Catechin	—	51
37	plumbagin [Supplementary Concept]	—	300
38	Resveratrol	—	298
39	Rutin	—	300
40	Anthralin	—	299
41	butein	—	158
42	Cimetidine	—	299
43	Dihydroxyphenylalanine	—	300
44	Estramustine	—	300
45	o-Phthalaldehyde	—	300
46	rafoxanide	—	172
47	Suramin	—	300
48	Thioctic Acid	—	300
49	Cisplatin	—	300
50	alphitonin [Supplementary Concept] from	—	300

About the Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template Pathway

The Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template pathway is catalogued in Reactome (ID: R-HSA-110313) and involves 6 genes. In the BiohacksAI corpus, 59 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include PCNA, POLH, POLI, POLK, USP10.