Resolution of AP sites via the multiple-nucleotide patch replacement pathway

Q: What compounds affect the Resolution of AP sites via the multiple-nucleotide patch replacement pathway pathway?

57 compounds in the BiohacksAI corpus have documented interactions with genes in the Resolution of AP sites via the multiple-nucleotide patch replacement pathway pathway (Reactome ID: R-HSA-110373). These compounds target 5 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-1103735 genes57 compounds

The Resolution of AP sites via the multiple-nucleotide patch replacement pathway pathway (Reactome ID: R-HSA-110373) involves 5 genes and is affected by 57 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

APEX1 FEN1 PARP1 PCNA POLB

Compounds Affecting Resolution of AP sites via the multiple-nucleotide patch replacement pathway

#	Compound	Targets Hit	Studies
1	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
2	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
3	Aurintricarboxylic Acid	—	184
4	Oleanolic Acid	—	300
5	Methyldopa	—	297
6	Methylene Blue	—	200
7	Quercetin	—	300
8	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
9	Idarubicin	—	299
10	Oxytetracycline	—	300
11	piceatannol	—	300
12	streptonigrin	—	299
13	stigmasterol	—	300
14	4-Hydroxybenzoate-3-Monooxygenase	—	300
15	Ursolic Acid	—	300
16	DEAD-box RNA Helicases	—	169
17	Thioctic Acid	—	298
18	egcg	—	300
19	Rosmarinic Acid	—	300
20	Rutin	—	300
21	Methotrexate	—	289
22	calycosin	—	300
23	Demeclocycline	—	5
24	Dequalinium	—	46
25	Hexachlorophene	—	300
26	Nitroprusside	—	299
27	sp600125	—	117
28	Stavudine	—	298
29	alphitonin [Supplementary Concept] from	—	300
30	Thioctic Acid	—	300
31	Norepinephrine Precursor of epinephrine that is secreted by	—	298
32	Dequalinium	—	136
33	Diiodotyrosine	—	300
34	Epinephrine	—	299
35	Ethidium	—	300
36	Levodopa	—	297
37	Doxycycline	—	999
38	Carmine Coloring matter from	—	300
39	Cisplatin	—	300
40	Demeclocycline	—	297
41	Dithiazanine 3-Ethyl-2-(5-(3-ethyl-2-benzothiazolinylidene)-1,3- pentadienyl)benzothiazolium.	—	135
42	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	—	299
43	Bortezomib	—	300
44	Camptothecin	—	300
45	Clofarabine	—	298
46	Daunorubicin	—	298
47	Demecolcine	—	246
48	Epirubicin	—	300
49	Gemcitabine	—	300
50	Homoharringtonine Semisynthetic derivative of harringtonine that acts as	—	300

About the Resolution of AP sites via the multiple-nucleotide patch replacement pathway Pathway

The Resolution of AP sites via the multiple-nucleotide patch replacement pathway pathway is catalogued in Reactome (ID: R-HSA-110373) and involves 5 genes. In the BiohacksAI corpus, 57 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include APEX1, FEN1, PARP1, PCNA, POLB.