What compounds affect the Apoptotic factor-mediated response pathway?

25 compounds in the BiohacksAI corpus have documented interactions with genes in the Apoptotic factor-mediated response pathway (Reactome ID: R-HSA-111471). These compounds target 4 genes within this pathway.

What genes are in the Apoptotic factor-mediated response pathway?

The Apoptotic factor-mediated response pathway involves 4 genes. Key genes include: CASP9, GSDMD, MAPK1, MAPK3.

Apoptotic factor-mediated response

REACTOME PATHWAY

Reactome: R-HSA-1114714 genes25 compounds

The Apoptotic factor-mediated response pathway (Reactome ID: R-HSA-111471) involves 4 genes and is affected by 25 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CASP9 GSDMD MAPK1 MAPK3

Compounds Affecting Apoptotic factor-mediated response

#	Compound	Targets Hit	Studies
1	plumbagin [Supplementary Concept]	—	300
2	pd98059	—	7
3	alsterpaullone	—	12
4	kenpaullone	—	8
5	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
6	Sorafenib	—	300
7	trametinib	—	296
8	withaferin	—	300
9	tyrphostin ag 1478	—	4
10	Clotrimazole	—	296
11	sp600125	—	117
12	fisetin	—	78
13	Progesterone	—	299
14	2-Chloroadenosine 2-Chloroadenosine.	—	300
15	Benzalkonium Compounds	—	299
16	Calcimycin	—	216
17	daph	—	2
18	Diphenhydramine	—	14
19	ha1004	—	4
20	Lithocholic Acid	—	300
21	Loratadine	—	296
22	trequinsin hydrochloride	—	1
23	Methylene Blue	—	200
24	felbinac	—	31
25	Disulfiram	—	297

About the Apoptotic factor-mediated response Pathway

The Apoptotic factor-mediated response pathway is catalogued in Reactome (ID: R-HSA-111471) and involves 4 genes. In the BiohacksAI corpus, 25 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CASP9, GSDMD, MAPK1, MAPK3.