What compounds affect the ISG15 antiviral mechanism pathway?

38 compounds in the BiohacksAI corpus have documented interactions with genes in the ISG15 antiviral mechanism pathway (Reactome ID: R-HSA-1169408). These compounds target 9 genes within this pathway.

What genes are in the ISG15 antiviral mechanism pathway?

The ISG15 antiviral mechanism pathway involves 9 genes. Key genes include: EIF2AK2, EIF4A1, EIF4G1, KPNB1, MAPK3, PIN1, PPM1B, STAT1, UBE2N.

ISG15 antiviral mechanism

REACTOME PATHWAY

Reactome: R-HSA-11694089 genes38 compounds

The ISG15 antiviral mechanism pathway (Reactome ID: R-HSA-1169408) involves 9 genes and is affected by 38 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

EIF2AK2 EIF4A1 EIF4G1 KPNB1 MAPK3 PIN1 PPM1B STAT1 UBE2N

Compounds Affecting ISG15 antiviral mechanism

#	Compound	Targets Hit	Studies
1	Chlorhexidine	—	299
2	Hexachlorophene	—	300
3	naringin	—	300
4	Perphenazine	—	297
5	Sphingosine	—	300
6	Resveratrol	—	298
7	Sertraline	—	1,000
8	Astemizole Antihistamine drug now withdrawn from	—	280
9	Canrenone	—	300
10	Thioridazine	—	35
11	plumbagin [Supplementary Concept]	—	300
12	pd98059	—	7
13	alsterpaullone	—	12
14	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
15	kenpaullone	—	8
16	Sorafenib	—	300
17	trametinib	—	296
18	withaferin	—	300
19	DEAD-box RNA Helicases	—	169
20	Thioctic Acid	—	298
21	Thioctic Acid	—	300
22	Azauridine	—	300
23	Levetiracetam	—	296
24	Oxytetracycline	—	300
25	Budesonide	—	1,000
26	Methylene Blue	—	200
27	egcg	—	300
28	Flurandrenolone	—	65
29	streptonigrin	—	299
30	Axitinib	—	298
31	Crizotinib	—	298
32	sp600125	—	117
33	cycloheximide	—	300
34	Adenosine Diphosphate Adenosine 5'-(trihydrogen diphosphate).	—	300
35	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
36	Aurintricarboxylic Acid	—	184
37	Reserpine	—	297
38	Okadaic Acid	—	300

About the ISG15 antiviral mechanism Pathway

The ISG15 antiviral mechanism pathway is catalogued in Reactome (ID: R-HSA-1169408) and involves 9 genes. In the BiohacksAI corpus, 38 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include EIF2AK2, EIF4A1, EIF4G1, KPNB1, MAPK3.