Prolactin receptor signaling
REACTOME PATHWAYThe Prolactin receptor signaling pathway (Reactome ID: R-HSA-1170546) involves 4 genes and is affected by 19 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Prolactin receptor signaling
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | ninhydrin | — | 300 |
| 2 | Azauridine | — | 300 |
| 3 | Cladribine | — | 297 |
| 4 | Dasatinib | — | 299 |
| 5 | Methylene Blue | — | 200 |
| 6 | 2-Methoxyestradiol | — | 300 |
| 7 | Astemizole Antihistamine drug now withdrawn from | — | 280 |
| 8 | Azathioprine | — | 300 |
| 9 | Calcitriol | — | 300 |
| 10 | Camptothecin | — | 300 |
| 11 | Cytarabine | — | 297 |
| 12 | dihydrorotenone | — | 13 |
| 13 | Podophyllotoxin | — | 14 |
| 14 | streptonigrin | — | 299 |
| 15 | Trifluridine | — | 295 |
| 16 | Tripterygium | — | 300 |
| 17 | candesartan cilexetil [Supplementary Concept] | — | 300 |
| 18 | Cetylpyridinium Cationic bactericidal surfactant used as | — | 300 |
| 19 | Sorafenib | — | 300 |
About the Prolactin receptor signaling Pathway
The Prolactin receptor signaling pathway is catalogued in Reactome (ID: R-HSA-1170546) and involves 4 genes. In the BiohacksAI corpus, 19 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CUL1, JAK2, RBX1, STAT5A.