What compounds affect the Meiotic synapsis pathway?

35 compounds in the BiohacksAI corpus have documented interactions with genes in the Meiotic synapsis pathway (Reactome ID: R-HSA-1221632). These compounds target 2 genes within this pathway.

What genes are in the Meiotic synapsis pathway?

The Meiotic synapsis pathway involves 2 genes. Key genes include: BRCA1, LMNA.

Meiotic synapsis

REACTOME PATHWAY

Reactome: R-HSA-12216322 genes35 compounds

The Meiotic synapsis pathway (Reactome ID: R-HSA-1221632) involves 2 genes and is affected by 35 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

BRCA1 LMNA

Compounds Affecting Meiotic synapsis

#	Compound	Targets Hit	Studies
1	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
2	Resveratrol	—	298
3	Methotrexate	—	289
4	Astemizole Antihistamine drug now withdrawn from	—	280
5	Azacitidine	—	298
6	Azacitidine	—	300
7	Calcimycin	—	216
8	calycosin	—	300
9	Chlorhexidine	—	299
10	Ciclopirox	—	88
11	Colchicine	—	300
12	colchine	—	2
13	cycloheximide	—	300
14	Cytarabine	—	297
15	Demecolcine	—	246
16	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
17	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
18	dihydrorotenone	—	13
19	Fluspirilene	—	74
20	gedunin	—	54
21	Hexachlorophene	—	300
22	lidoflazine	—	278
23	Melphalan	—	300
24	Niclosamide	—	299
25	Nocodazole Nocodazole is	—	215
26	paxilline	—	42
27	Podophyllotoxin	—	14
28	rafoxanide	—	172
29	Semustine 4-Methyl derivative of LOMUSTINE; (CCNU).	—	97
30	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
31	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	—	299
32	Trifluridine	—	295
33	Tubercidin	—	300
34	vinblastine sulfate	—	81
35	Histamine	—	300

About the Meiotic synapsis Pathway

The Meiotic synapsis pathway is catalogued in Reactome (ID: R-HSA-1221632) and involves 2 genes. In the BiohacksAI corpus, 35 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include BRCA1, LMNA.